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    Mpg N-methylpurine-DNA glycosylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mpgprovided by RGD
    Official Full Name
    N-methylpurine-DNA glycosylaseprovided by RGD
    Primary source
    RGD:3106
    See related
    EnsemblRapid:ENSRNOG00000020571 AllianceGenome:RGD:3106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alkylbase DNA N-glycosylase activity. Predicted to be involved in base-excision repair. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Orthologous to human MPG (N-methylpurine DNA glycosylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 44.9), Spleen (RPKM 43.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpg in Genome Data Viewer
    Location:
    10q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15900697..15906981, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15396246..15402528, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15661768..15667995, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hemoglobin subunit zeta Neighboring gene NPR3-like, GATOR1 complex subunit Neighboring gene rhomboid 5 homolog 1 Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and structure of a cDNA expressing a mammalian 3-methyladenine-DNA glycosylase. O'Connor TR, et al. EMBO J, 1990 Oct. PMID 1698614, Free PMC Article
    2. New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo. Ham AJ, et al. DNA Repair (Amst), 2004 Mar 4. PMID 15177041
    3. Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine. Hang B, et al. Proc Natl Acad Sci U S A, 1997 Nov 25. PMID 9371767, Free PMC Article
    4. Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11. Engelward BP, et al. Carcinogenesis, 1993 Feb. PMID 8435858
    5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-3-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-3-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-5-methylcytosine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-7-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-7-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alkylbase DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkylbase DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-3-methyladenine glycosylase
    Names
    3-alkyladenine DNA glycosylase
    3-methyladenine DNA glycosidase
    ADPG
    N-methylpurine-DNA glycocylase
    NP_036733.2
    XP_038941119.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429907.1 → NP_001416836.1  DNA-3-methyladenine glycosylase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HDB2

    2. NM_012601.3 → NP_036733.2  DNA-3-methyladenine glycosylase isoform 1

      See identical proteins and their annotated locations for NP_036733.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HDB1, D3ZEM0
      Related
      ENSRNOP00000073752.3, ENSRNOT00000085746.3
      Conserved Domains (1) summary
      TIGR00567
      Location:105 → 305
      3mg; DNA-3-methyladenine glycosylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15900697..15906981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085191.2 → XP_038941119.1  DNA-3-methyladenine glycosylase isoform X1

      Conserved Domains (1) summary
      cl14785
      Location:109 → 192
      FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23571.2 GenPept UniProtKB/Swiss-Prot:P23571

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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