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    SWC3 Swc3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SWC3
    Official Full Name
    Swc3p
    Primary source
    SGD:S000000009
    Locus tag
    YAL011W
    See related
    AllianceGenome:SGD:S000000009; FungiDB:YAL011W; VEuPathDB:YAL011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SWC1
    Summary
    Predicted to enable ATP-dependent H2AZ histone chaperone activity. Involved in chromatin remodeling and endoplasmic reticulum organization. Located in mitochondrion and nucleus. Part of Swr1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SWC3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (132199..134076)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Rpd3L histone deacetylase complex subunit DEP1 Neighboring gene cystathionine gamma-lyase CYS3 Neighboring gene Mdm10p Neighboring gene Nem1-Spo7 phosphatase regulatory subunit SPO7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parallel analysis of tagged deletion mutants efficiently identifies genes involved in endoplasmic reticulum biogenesis. Wright R, et al. Yeast, 2003 Jul 30. PMID 12868057
    2. Roles for H2A.Z and its acetylation in GAL1 transcription and gene induction, but not GAL1-transcriptional memory. Halley JE, et al. PLoS Biol, 2010 Jun 22. PMID 20582323, Free PMC Article
    3. What makes a histone variant a variant: Changing H2A to become H2A.Z. Brewis HT, et al. PLoS Genet, 2021 Dec. PMID 34871303, Free PMC Article
    4. Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Wang AY, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 19966225, Free PMC Article
    5. Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Emre NC, et al. Mol Cell, 2005 Feb 18. PMID 15721261

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swr1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Swc3p
    NP_009391.2
    • hypothetical protein; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      132199..134076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178156.1 → NP_009391.2  TPA: Swc3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009391.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPK7, P31376
      UniProtKB/TrEMBL
      A7A0F8, N1P7K9
      Conserved Domains (1) summary
      PTZ00108
      Location:211 → 439
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31376.2

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