Preb prolactin regulatory element binding [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prebprovided by RGD
Official Full Name: prolactin regulatory element bindingprovided by RGD
Primary source: RGD:61929
See related: EnsemblRapid:ENSRNOG00000007141 AllianceGenome:RGD:61929
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mSec12
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in COPII vesicle coating and positive regulation of transcription by RNA polymerase II. Is active in endoplasmic reticulum membrane. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 254.5), Muscle (RPKM 212.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (31138757..31142544)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25418805..25422594)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (26784088..26787875)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PREB regulates the cAMP-mediated transcription of the ABCA1 gene in vascular smooth muscle cells
Title: Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate.
PREB can function as a transcriptional regulator of prolactin promoter activity and might be involved in TRH-induced PRL gene transcription
Title: The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells.
The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells.
Title: The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells.
PREB may contribute to the regulation of insulin gene transcription and insulin secretion in response to glucose stimulation.
Title: Prolactin regulatory element binding protein as a potential transcriptional factor for the insulin gene in response to glucose stimulation.

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General gene information

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Markers

MARC_49992-49993:1124119588:2 (e-PCR)
- UniSTS:477502

AI547393 (e-PCR)
- UniSTS:249784

RH136976 (e-PCR)
- UniSTS:219065

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of COPII vesicle coating	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of COPII vesicle coating	IEA Inferred from Electronic Annotation more info
involved_in regulation of COPII vesicle coating	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum exit site	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum exit site	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanine nucleotide-exchange factor SEC12

Names: mammalian guanine nucleotide exchange factor Sec12; mammalian guanine nucleotide exchange factor mSec12; prolactin regulatory element-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170708.1 → NP_001164179.1 guanine nucleotide-exchange factor SEC12

See identical proteins and their annotated locations for NP_001164179.1

Status: PROVISIONAL

Source sequence(s)

BC078936

UniProtKB/Swiss-Prot

Q6AYS1, Q9WTV0

UniProtKB/TrEMBL

A6HAA1, G3V6W2

Related

ENSRNOP00000009566.5, ENSRNOT00000009565.8

Conserved Domains (3) summary

COG2319
Location:140 → 354

WD40; WD40 repeat [General function prediction only]

sd00039
Location:16 → 67

7WD40; WD40 repeat [structural motif]

cl02567
Location:159 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...