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    PHO3 acid phosphatase PHO3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PHO3
    Official Full Name
    acid phosphatase PHO3
    Primary source
    SGD:S000000296
    Locus tag
    YBR092C
    See related
    AllianceGenome:SGD:S000000296; FungiDB:YBR092C; VEuPathDB:YBR092C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables acid phosphatase activity. Involved in phosphate-containing compound metabolic process and thiamine-containing compound metabolic process. Located in cell wall-bounded periplasmic space. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PHO3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (427698..429101, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene high-mobility group nucleosome-binding protein Neighboring gene Tim12p Neighboring gene acid phosphatase PHO5 Neighboring gene putative tubulin tyrosine ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A possible role for acid phosphatase with thiamin-binding activity encoded by PHO3 in yeast. Nosaka K, et al. FEMS Microbiol Lett, 1989 Jul 1. PMID 2676709
    2. Molecular cloning, expression and evaluation of phosphohydrolases for phytate-degrading activity. Moore E, et al. J Ind Microbiol, 1995 May. PMID 7612216
    3. Two yeast acid phosphatase structural genes are the result of a tandem duplication and show different degrees of homology in their promoter and coding sequences. Meyhack B, et al. EMBO J, 1982. PMID 6329697, Free PMC Article
    4. Acid phosphatase polypeptides in Saccharomyces cerevisiae are encoded by a differentially regulated multigene family. Rogers DT, et al. Proc Natl Acad Sci U S A, 1982 Apr. PMID 6212932, Free PMC Article
    5. Structural analysis of the two tandemly repeated acid phosphatase genes in yeast. Bajwa W, et al. Nucleic Acids Res, 1984 Oct 25. PMID 6093051, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effect of Deletions of the Genes Encoding Pho3p and Bgl2p on Polyphosphate Level, Stress Adaptation, and Attachments of These Proteins to Saccharomyces cerevisiae Cell Wall.
      Title: Effect of Deletions of the Genes Encoding Pho3p and Bgl2p on Polyphosphate Level, Stress Adaptation, and Attachments of These Proteins to Saccharomyces cerevisiae Cell Wall.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphate-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thiamine-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell wall-bounded periplasmic space IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    acid phosphatase PHO3
    NP_009650.1
    • Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      427698..429101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178440.1 → NP_009650.1  TPA: acid phosphatase PHO3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009650.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ93, P24031
      UniProtKB/TrEMBL
      D3UEI7
      Conserved Domains (1) summary
      pfam00328
      Location:65 → 399
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24031.2

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