U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nod no distributive disjunction [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32107, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nodprovided by FlyBase
    Official Full Name
    no distributive disjunctionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002948
    Locus tag
    Dmel_CG1763
    See related
    AllianceGenome:FB:FBgn0002948
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1763; Dmel\CG1763; DmNod; DnMod; KIF 22; KIF22; l(1)TW6; Nod; NOD
    Summary
    Enables microtubule motor activity and microtubule plus-end binding activity. Involved in establishment of meiotic spindle orientation; meiotic chromosome segregation; and positive regulation of microtubule polymerization. Part of kinesin complex. Is expressed in several structures, including anlage in statu nascendi; central brain anlage; central brain anlage in statu nascendi; ganglia; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nod in Genome Data Viewer
    Location:
    10C7-10C8; 1-35 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11580772..11585750)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11474805..11479783)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA on the X 2 Neighboring gene Pinkman Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic variation in rates of nondisjunction: association of two naturally occurring polymorphisms in the chromokinesin nod with increased rates of nondisjunction in Drosophila melanogaster. Zwick ME, et al. Genetics, 1999 Aug. PMID 10430586, Free PMC Article
    2. ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement. Cochran JC, et al. Cell, 2009 Jan 9. PMID 19135893, Free PMC Article
    3. A meiotic mutant defective in distributive disjunction in Drosophila melanogaster. Carpenter AT. Genetics, 1973 Mar. PMID 4633612, Free PMC Article
    4. Chromosome yield new clue to pairing in meiosis. Marx J. Science, 1996 Jul 5. PMID 8658189
    5. Riding the polar winds: chromosomes motor down east. Fuller MT. Cell, 1995 Apr 7. PMID 7720073

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NOD produces congression forces by microtubule plus end-directed motility and tip-tracking on polymerizing microtubule plus ends via association with EB1.
      Title: NOD is a plus end-directed motor that binds EB1 via a new microtubule tip localization sequence.
    2. Upon rapid substrate binding, NOD detaches from the microtubule prior to the rate-limiting step of ATP hydrolysis, which is also atypical for a kinesin; leading to model for NOD's microtubule plus-end tracking that drives chromosome movement.
      Title: ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement.
    3. Orphan kinesin NOD lacks motile properties but does possess a microtubule-stimulated ATPase activity
      Title: Orphan kinesin NOD lacks motile properties but does possess a microtubule-stimulated ATPase activity.
    4. Recognition of a bicoid mRNA localization signal by a protein complex containing Swallow, Nod, and RNA binding proteins.
      Title: Recognition of a bicoid mRNA localization signal by a protein complex containing Swallow, Nod, and RNA binding proteins.
    5. The observation that Nod is preferentially localized to the plus ends of MTs and stimulates MT polymerization suggests a mechanism for its function.
      Title: Drosophila Nod protein binds preferentially to the plus ends of microtubules and promotes microtubule polymerization in vitro.
    6. The HhH2/NDD domain of the Drosophila Nod chromokinesin-like protein is required for binding to chromosomes in the oocyte nucleus.
      Title: The HhH2/NDD domain of the Drosophila Nod chromokinesin-like protein is required for binding to chromosomes in the oocyte nucleus.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in distributive segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of meiotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spindle assembly involved in female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    no distributive disjunction
    Names
    CG1763-PA
    CG1763-PB
    Kinesin4C
    No distributive disjunction
    kinesin-10
    kineskin-10
    nod-PA
    nod-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11580772..11585750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078570.3 → NP_511125.2  no distributive disjunction, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511125.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18105, Q9VYW9
      UniProtKB/TrEMBL
      X2JEV2
      Related
      FBpp0073363
      Conserved Domains (3) summary
      smart00129
      Location:8 → 325
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1555
      Location:540 → 648
      ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
      cd00106
      Location:8 → 318
      KISc; Kinesin motor domain

    2. NM_001298200.1 → NP_001285129.1  no distributive disjunction, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18105, Q9VYW9
      UniProtKB/TrEMBL
      X2JEV2
      Conserved Domains (3) summary
      smart00129
      Location:8 → 325
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1555
      Location:540 → 648
      ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
      cd00106
      Location:8 → 318
      KISc; Kinesin motor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18105.1 P18105
    X2JEV2 X2JEV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous