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    Pp2C1 Protein phosphatase 2C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pp2C1provided by FlyBase
    Official Full Name
    Protein phosphatase 2Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022768
    Locus tag
    Dmel_CG2984
    See related
    AllianceGenome:FB:FBgn0022768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.132; CG2984; Dmel\CG2984; dpp2c1; PP2C; PP2C1
    Summary
    Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of gene expression, epigenetic and regulation of intracellular signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pp2C1 in Genome Data Viewer
    Location:
    4C12-4C13; 1-8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4679988..4686903, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4574021..4580936, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene cap binding protein 80 Neighboring gene uncharacterized protein Neighboring gene fizzy-related Neighboring gene cut up Neighboring gene Pyruvate dehydrogenase E1 alpha subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila DPP2C1, a novel member of the protein phosphatase 2C (PP2C) family. Dick T, et al. Gene, 1997 Oct 15. PMID 9358049
    2. Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Jacobs H, et al. Curr Biol, 2002 Aug 20. PMID 12194827
    3. Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster. Iranmehr A, et al. Nat Commun, 2021 Feb 12. PMID 33579965, Free PMC Article
    4. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Wharton KA Jr. Dev Biol, 2003 Jan 1. PMID 12490194
    5. A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues. Parsons LM, et al. G3 (Bethesda), 2017 Aug 7. PMID 28611255, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 2C
    Names
    CG2984-PA
    CG2984-PB
    Pp2C1-PA
    Pp2C1-PB
    NP_001284867.1
    NP_525074.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4679988..4686903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297938.1 → NP_001284867.1  protein phosphatase 2C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77023, Q8T036, Q9W4H8
      Conserved Domains (1) summary
      cd00143
      Location:256 → 567
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. NM_080335.3 → NP_525074.2  protein phosphatase 2C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525074.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77023, Q8T036, Q9W4H8
      Related
      FBpp0070653
      Conserved Domains (1) summary
      cd00143
      Location:256 → 567
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77023 O77023
    Q9W4H8 Q9W4H8

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