M1BP Motif 1 Binding Protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: M1BPprovided by FlyBase
Official Full Name: Motif 1 Binding Proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0037621
Locus tag: Dmel_CG9797
See related: AllianceGenome:FB:FBgn0037621
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CC31; CG9797; Dmel\CG9797
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in RNA polymerase II preinitiation complex assembly; follicle cell of egg chamber development; and positive regulation of transcription by RNA polymerase II. Colocalizes with euchromatin. Is expressed in several structures, including CNS glial cell; anterior endoderm; anterior endoderm anlage; ganglia; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85A9-85A9; 3-48 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8729790..8731698, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4555512..4557420, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development.
Title: M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development.
M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
Title: M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
Motif 1 Binding Protein suppresses wingless to promote eye fate in Drosophila.
Title: Motif 1 Binding Protein suppresses wingless to promote eye fate in Drosophila.
Human ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy regulation.
Title: Human ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy regulation.
Although M1BP associates with thousands of genes, its colocalization with TRF2 is largely restricted to Ribosomal proteins genes, suggesting that this combination is key to coordinately regulating transcription of the majority of Ribosomal Proteins genes in Drosophila.
Title: A sequence-specific core promoter-binding transcription factor recruits TRF2 to coordinately transcribe ribosomal protein genes.
Identification of a two-step mechanism of Hox-driven transcription, with M1BP binding leading to Pol II recruitment followed by AbdA targeting, which results in a change in the chromatin landscape and enhanced transcription.
Title: The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription.
GAF binding at promoters can lead to the local displacement of nucleosomes, but this activity can be restricted or compensated for when insulator protein or M1BP complexes also reside at GAF bound promoters.
Title: GAGA factor maintains nucleosome-free regions and has a role in RNA polymerase II recruitment to promoters.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	HGI more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
colocalizes_with euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: motif 1 binding protein

Names: CG9797-PA; M1BP-PA; Motif-1-binding protein; motif 1-binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8729790..8731698 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141568.3 → NP_649825.1 motif 1 binding protein [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649825.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VHM3

Related

FBpp0081428

Conserved Domains (4) summary

smart00868
Location:13 → 84

zf-AD; Zinc-finger associated domain (zf-AD)

COG5048
Location:276 → 331

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:281 → 301

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:293 → 317

zf-H2C2_2; Zinc-finger double domain