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    iPLA2-VIA calcium-independent phospholipase A2 VIA [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    iPLA2-VIAprovided by FlyBase
    Official Full Name
    calcium-independent phospholipase A2 VIAprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036053
    Locus tag
    Dmel_CG6718
    See related
    AllianceGenome:FB:FBgn0036053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6718; diPLA2-VIA; Dmel\CG6718; iPLA2beta; iPLA[[2]]-VIA; PLA2G6
    Summary
    Enables retromer complex binding activity. Involved in positive regulation of response to oxidative stress; regulation of ceramide biosynthetic process; and triglyceride homeostasis. Located in mitochondrion. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval garland cell; ganglia; and primordial germ cell. Used to study Parkinson's disease 14; neurodegeneration with brain iron accumulation 2a; and neurodegenerative disease. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See iPLA2-VIA in Genome Data Viewer
    Location:
    67C11-67C11; 3-31 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9860217..9864349, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9853317..9857449, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ras GTPase activating protein 1 Neighboring gene uncharacterized protein Neighboring gene Ciz1 zinc finger protein Neighboring gene long non-coding RNA:CR45406

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation. Kinghorn KJ, et al. Rare Dis, 2016. PMID 27141409, Free PMC Article
    2. Psychomotor Behavior: A Practical Approach in Drosophila. Iliadi KG, et al. Front Psychiatry, 2016. PMID 27630583, Free PMC Article
    3. Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14). Lin G, et al. Elife, 2023 Jan 16. PMID 36645408, Free PMC Article
    4. Lipidome-wide (13)C flux analysis: a novel tool to estimate the turnover of lipids in organisms and cultures. Schlame M, et al. J Lipid Res, 2020 Jan. PMID 31712250, Free PMC Article
    5. A course-based undergraduate research experience examining neurodegeneration in Drosophila melanogaster teaches students to think, communicate, and perform like scientists. Delventhal R, et al. PLoS One, 2020. PMID 32282825, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. iPLA2-VIA is required for healthy aging of neurons, muscle, and the female germline in Drosophila melanogaster.
      Title: iPLA2-VIA is required for healthy aging of neurons, muscle, and the female germline in Drosophila melanogaster.
    2. iPLA2-VIA binds the retromer subunits Vps35 and Vps26 and enhances retromer function to promote protein and lipid recycling. iPLA2-VIA regulates ceramide and sphingolipid metabolism.
      Title: Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain.
    3. a role of ALDHs as major contributors to the homeostasis of pyridine nucleotides in plants
      Title: Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration.
    4. our findings demonstrate that loss of normal PLA2G6 gene activity leads to lipid peroxidation, mitochondrial dysfunction and subsequent mitochondrial membrane abnormalities.
      Title: Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-independent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-independent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables retromer complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in cardiolipin acyl-chain remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ceramide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of sphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium-independent phospholipase A2 VIA
    Names
    CG6718-PA
    CG6718-PB
    CG6718-PC
    CG6718-PD
    iPLA2-VIA-PA
    iPLA2-VIA-PB
    iPLA2-VIA-PC
    iPLA2-VIA-PD
    phospholipase A[[2]]
    NP_648366.2
    NP_729565.2
    NP_729566.2
    NP_729567.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9860217..9864349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140109.2 → NP_648366.2  calcium-independent phospholipase A2 VIA, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648366.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R25, Q9VT60
      Related
      FBpp0076091
      Conserved Domains (4) summary
      cd07212
      Location:553 → 866
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      cd00204
      Location:281 → 402
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:287 → 376
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:282 → 310
      ANK; ANK repeat [structural motif]

    2. NM_168383.2 → NP_729565.2  calcium-independent phospholipase A2 VIA, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729565.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R25, Q7KUD4
      Related
      FBpp0076092
      Conserved Domains (4) summary
      cd07212
      Location:563 → 876
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      cd00204
      Location:291 → 412
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:297 → 386
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:292 → 320
      ANK; ANK repeat [structural motif]

    3. NM_168385.2 → NP_729567.2  calcium-independent phospholipase A2 VIA, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729567.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R25, Q7KUD4
      Related
      FBpp0076094
      Conserved Domains (4) summary
      cd07212
      Location:563 → 876
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      cd00204
      Location:291 → 412
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:297 → 386
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:292 → 320
      ANK; ANK repeat [structural motif]

    4. NM_168384.2 → NP_729566.2  calcium-independent phospholipase A2 VIA, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729566.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R25, Q7KUD4
      Related
      FBpp0076093
      Conserved Domains (4) summary
      cd07212
      Location:563 → 876
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      cd00204
      Location:291 → 412
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:297 → 386
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:292 → 320
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KUD4 Q7KUD4
    Q8MR13 Q8MR13
    Q9VT60 Q9VT60

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