hb hunchback [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hbprovided by FlyBase
Official Full Name: hunchbackprovided by FlyBase
Primary source: FLYBASE:FBgn0001180
Locus tag: Dmel_CG9786
See related: AllianceGenome:FB:FBgn0001180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9786; Dm-hb; Dm-Hb; Dmel\CG9786; Hb; HB; hbHLH; Hunchback; l(3)85Ah; R-pbx; Rg-bx; Rg-pbx
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including neuroblast fate determination; regulation of neural precursor cell proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; glial cell; head epidermis primordium; larval neurons; and somatic precursor cell. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85A5-85A5; 3-48 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8690980..8697822, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4516702..4523544, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts.
Title: Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts.
Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
Title: Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
Title: Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute.
Title: A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute.
Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci.
Title: Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci.
The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila
Title: The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila.
These data show Hb acts as a potent regulator of neuromuscular wiring decisions.
Title: How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits.
Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter.
Title: Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter.
While Hunchback directly represses the eve stripe 3+7 enhancer, study found that in the eve stripe 2+7 enhancer, Hunchback repression is prevented by nearby sequences-this phenomenon is called counter-repression.
Title: Hunchback is counter-repressed to regulate even-skipped stripe 2 expression in Drosophila embryos.
Hunchback (Hb) regulates a significant number of genes that are expressed during late differentiation stages. Hb is expressed in two polyploid subperineurial glia cells (carpet cells) and a thorough functional analysis shows that loss of Hb function results in a loss of carpet cells in the eye-antennal disc.
Title: Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ganglion mother cell fate determination	TAS Traceable Author Statement more info	PubMed
involved_in generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate determination	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuroblast fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior head segmentation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of development, heterochronic	TAS Traceable Author Statement more info	PubMed
involved_in regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in salivary gland development	TAS Traceable Author Statement more info	PubMed
involved_in trunk segmentation	TAS Traceable Author Statement more info	PubMed
involved_in ventral cord development	NAS Non-traceable Author Statement more info	PubMed
involved_in zygotic determination of anterior/posterior axis, embryo	NAS Non-traceable Author Statement more info	PubMed
involved_in zygotic determination of anterior/posterior axis, embryo	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: hunchback

Names: CG9786-PA; CG9786-PB; Regulator-of-postbithorax; hb-PA; hb-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8690980..8697822 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169233.2 → NP_731267.1 hunchback, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731267.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P05084, Q24018, Q29R06, Q960U7

Related

FBpp0081432

Conserved Domains (3) summary

sd00017
Location:271 → 291

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:707 → 727

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:283 → 308

zf-H2C2_2; Zinc-finger double domain
NM_169234.2 → NP_731268.1 hunchback, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731268.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P05084, Q24018, Q29R06, Q960U7

Related

FBpp0081431

Conserved Domains (3) summary

sd00017
Location:271 → 291

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:707 → 727

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:283 → 308

zf-H2C2_2; Zinc-finger double domain