NetA Netrin-A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: NetAprovided by FlyBase
Official Full Name: Netrin-Aprovided by FlyBase
Primary source: FLYBASE:FBgn0015773
Locus tag: Dmel_CG18657
See related: AllianceGenome:FB:FBgn0015773
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18657; CT27014; Dmel\CG18657; net; netA; netrin; Netrin; netrin A; NetrinA
Summary: Involved in compound eye development; neurogenesis; and regulation of photoreceptor cell axon guidance. Located in axonal growth cone. Is expressed in several structures, including A1-7 dorsal acute muscle cell; epithelium; head epidermis primordium; midline glial cell; and segmentally-repeated neuroblast. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to several human genes including NTN1 (netrin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12F1-12F2; 1-49 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (14604012..14653928, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (14498045..14547961, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Axon targeting of Drosophila medulla projection neurons requires diffusible Netrin and is coordinated with neuroblast temporal patterning.
Title: Axon targeting of Drosophila medulla projection neurons requires diffusible Netrin and is coordinated with neuroblast temporal patterning.
Frazzled/Dcc acts independently of Netrin to promote germline survival during Drosophila oogenesis.
Title: Frazzled/Dcc acts independently of Netrin to promote germline survival during Drosophila oogenesis.
Here we show that M3-specific innervation by both neurons is coordinated by Drosophila Fezf (dFezf), a conserved transcription factor that is selectively expressed by the earlier targeting input neuron. In this cell, dFezf instructs layer specificity and activates the expression of a secreted molecule (Netrin) that regulates the layer specificity of the other input neuron.
Title: Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms.
mutation of mushroom body defect (mud) dramatically enhances the phenotype of Netrin or frazzled mutants, resulting in many more axons failing to cross the midline, although mutations in mud alone have little effect.
Title: Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila.
Contact-mediated cell adhesion via Fmi acts in addition to the Net/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development.
Title: Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.
adult Drosophila lacking both netrin genes, NetA and NetB, have fertility defects in both sexes together with an inability to fly and reduced viability.
Title: Control of male and female fertility by the netrin axon guidance genes.
In peripodial cells Frazzled is endocytosed and undergoes NetA-dependent degradation, which is required for eversion.
Title: Netrin-dependent downregulation of Frazzled/DCC is required for the dissociation of the peripodial epithelium in Drosophila.
These data are the first to show that Netrin and Frazzled regulate the placement of gap junctions presynaptically at a synapse.
Title: Netrin and Frazzled regulate presynaptic gap junctions at a Drosophila giant synapse.
NetA and semaphorin-1a can specifically promote growth through induction of key cellular growth regulators.
Title: Induction of cellular growth by the axon guidance regulators netrin A and semaphorin-1a.
Misexpression of Netrin-A in oenocytes, secretory cells that lie ventral to the cap cell, leads to aberrant cap cell morphogenesis, suggesting that Netrin-A acts as an instructive cue to direct the growth of the cap cell process.
Title: Netrin-guided accessory cell morphogenesis dictates the dendrite orientation and migration of a Drosophila sensory neuron.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c14641895-14636525 mobile_element_type = transposon:I{}129

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axonal growth cone	IGI Inferred from Genetic Interaction more info	PubMed
located_in axonal growth cone	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Netrin-A

Names: CG18657-PA; CG18657-PB; CG18657-PC; D-netrin; D-netrin-A; NetA-PA; NetA-PB; NetA-PC; NetrinA; netrin; netrin A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

14604012..14653928 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298314.1 → NP_001285243.1 Netrin-A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285243.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24567, Q7JXY0, Q94528, Q9VY25

UniProtKB/TrEMBL

X2JEZ9

Conserved Domains (3) summary

smart00136
Location:44 → 280

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:431 → 479

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:545 → 723

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
NM_078599.5 → NP_511154.3 Netrin-A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511154.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24567, Q7JXY0, Q94528, Q9VY25

UniProtKB/TrEMBL

X2JEZ9

Related

FBpp0073759

Conserved Domains (3) summary

smart00136
Location:44 → 280

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:431 → 479

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:545 → 723

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
NM_001258738.2 → NP_001245667.1 Netrin-A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245667.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NF48

Conserved Domains (3) summary

smart00136
Location:44 → 280

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:431 → 479

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam05091
Location:544 → 589

eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)