sbr small bristles [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sbrprovided by FlyBase
Official Full Name: small bristlesprovided by FlyBase
Primary source: FLYBASE:FBgn0003321
Locus tag: Dmel_CG1664
See related: AllianceGenome:FB:FBgn0003321
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1664; CG17335; CT4634; Dm nxf1; Dmel\CG1664; DmNXF1; DNXF-1; dNxf1; dNXF1; dTap; l(1)9Fd; l(1)G1; l(1)ts; l(1)ts403; nfx1; NFX1; nxf1; Nxf1; NXF1; NXF1-p15; PABPr; Sbr; SBR; sbt
Summary: Enables ribonucleoprotein complex binding activity. Involved in poly(A)+ mRNA export from nucleus and positive regulation of RNA export from nucleus. Located in nuclear membrane and nucleoplasm. Is expressed in several structures, including adult salivary gland; anterior-posterior subdivision of organism; embryonic/larval Malpighian tubule; gonad; and ventral nerve cord. Orthologous to several human genes including NXF1 (nuclear RNA export factor 1); NXF2 (nuclear RNA export factor 2); and NXF2B (nuclear RNA export factor 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 9F4-9F5; 1-33 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (10832752..10847092, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (10726785..10741125, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA-Binding Protein SBR (Dm NXF1) Is Required for the Constitution of Medulla Boundaries in Drosophila melanogaster Optic Lobes.
Title: The RNA-Binding Protein SBR (Dm NXF1) Is Required for the Constitution of Medulla Boundaries in Drosophila melanogaster Optic Lobes.
SFiNX, an interdependent protein complex, is required for Piwi-mediated cotranscriptional silencing in Drosophila. SFiNX consists of Nxf2-Nxt1, a gonad-specific variant of the heterodimeric messenger RNA export receptor Nxf1-Nxt1 and the Piwi-associated protein Panoramix. Within SFiNX, Panoramix recruits heterochromatin effectors, while the RNA binding protein Nxf2 licenses cotranscriptional silencing.
Title: The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
we show that the Dm NXF1 (SBR) protein is present not only in the nucleus but also in the cytoplasm
Title: Cytoplasmic localization of SBR (Dm NXF1) protein and its zonal distribution in the ganglia of Drosophila melanogaster larvae.
data indicate that origin recognition complex depletion affects the Nxf1 association with the mRNP complex.
Title: ORC interacts with THSC/TREX-2 and its subunits promote Nxf1 association with mRNP and mRNA export in Drosophila.
sbr12 deletion and short testis-specific isoforms of SBR cause male sterility.
Title: Testis-specific products of the Drosophila melanogaster sbr gene, encoding nuclear export factor 1, are necessary for male fertility.
For SBR protein we have shown the localization not only in the nucleus, but in the cytoplasm marking of characteristic cytoplasmic structures.
Title: [THE ROLE OF sbr/Dm nxf1 GENE DURING SYNCYTIAL PERIODS OF DEVELOPMENT IN DROSOPHILA MELANOGASTER].
Dm NXF1 (SBR) protein is present in considerable amounts at all stages of the spermatogenesis.
Title: [Spermatogenesis in Drosophila melanogaster: the role of the basic transport receptor of the mRNA (Dm NXF1)].
Alternative transcripts expressed by small bristles, the Drosophila melanogaster nxf1 gene
Title: Alternative transcripts expressed by small bristles, the Drosophila melanogaster nxf1 gene.
demonstrate that the SBR(5) mutant allele is a deletion of 492 nucleotides that removes 146 amino acids in the mutant SBR(5) protein.
Title: Dm nxf1/sbr gene affects the formation of meiotic spindle in female Drosophila melanogaster.
The frequency of abnormal chromosome sets in the offspring of male carriers of the sbr10 mutation is about two times higher than in the offspring of males without this mutation.
Title: [Hyperthermia of male Drosophila melanogaster meiocytes induces abnormalities in both paternal and maternal sex chromosome sets of the offspring].

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA export from nucleus	TAS Traceable Author Statement more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small bristles

Names: CG1664-PA; CG1664-PB; CG1664-PC; Nxf1; locus 1; nuclear export factor 1; sbr-PA; sbr-PB; sbr-PC; shorter-bristles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

10832752..10847092 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079921.3 → NP_524660.1 small bristles, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524660.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NFQ2, Q9NFQ3, Q9U1H9, Q9VZ65, Q9VZ68

Related

FBpp0073267

Conserved Domains (8) summary

smart00804
Location:609 → 671

TAP_C; C-terminal domain of vertebrate Tap protein

cd00116
Location:223 → 341

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00780
Location:372 → 531

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

sd00035
Location:215 → 255

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:112 → 191

Tap-RNA_bind; Tap, RNA-binding

pfam12799
Location:256 → 298

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:256 → 315

LRR_8; Leucine rich repeat

pfam16640
Location:578 → 614

Big_3_5; Bacterial Ig-like domain (group 3)
NM_001369981.1 → NP_001356941.1 small bristles, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K0P9

Conserved Domains (6) summary

smart00804
Location:473 → 535

TAP_C; C-terminal domain of vertebrate Tap protein

PRK06945
Location:412 → 477

flgK; flagellar hook-associated protein FlgK; Validated

cd00780
Location:236 → 395

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

sd00035
Location:79 → 119

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:4 → 55

Tap-RNA_bind; Tap, RNA-binding

pfam13855
Location:120 → 179

LRR_8; Leucine rich repeat
NM_001369982.1 → NP_001356942.1 small bristles, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K0P9

Conserved Domains (6) summary

smart00804
Location:473 → 535

TAP_C; C-terminal domain of vertebrate Tap protein

PRK06945
Location:412 → 477

flgK; flagellar hook-associated protein FlgK; Validated

cd00780
Location:236 → 395

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

sd00035
Location:79 → 119

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:4 → 55

Tap-RNA_bind; Tap, RNA-binding

pfam13855
Location:120 → 179

LRR_8; Leucine rich repeat