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    GABA-B-R3 metabotropic GABA-B receptor subtype 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GABA-B-R3provided by FlyBase
    Official Full Name
    metabotropic GABA-B receptor subtype 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031275
    Locus tag
    Dmel_CG3022
    See related
    AllianceGenome:FB:FBgn0031275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.13; anon-WO0170980.14; CG3022; D-GABA-B-R3; D-Gaba3; D-GABA[[B]]R3; Dmel\CG3022; GABA B R3; GABA-BR3; GABAb R3; GABAB(R3); GABA[[B]]-R3; GABA[[B]]R3; GB3
    Summary
    Predicted to enable G protein-coupled GABA receptor activity. Involved in sleep. Predicted to be located in membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Is expressed in larval brain; larval gnathal ganglion; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GABA-B-R3 in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (749945..762399)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (749945..762399)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Heat shock protein 60B Neighboring gene Excitatory amino acid transporter 2 Neighboring gene long non-coding RNA:CR44614 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional expression of GABA(B) receptors from Drosophila. Mezler M, et al. Eur J Neurosci, 2001 Feb. PMID 11168554
    2. High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model. Kong Y, et al. PLoS One, 2015. PMID 26361355, Free PMC Article
    3. A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. Haynes PR, et al. Elife, 2015 Jan 7. PMID 25564731, Free PMC Article
    4. Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila. Nakamizo-Dojo M, et al. Nat Commun, 2023 Oct 16. PMID 37845214, Free PMC Article
    5. Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe. Okada R, et al. J Comp Neurol, 2009 May 1. PMID 19260068

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled GABA receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled GABA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metabotropic GABA-B receptor subtype 3
    Names
    CG3022-PA
    CG3022-PC
    CG3022-PD
    CG3022-PE
    CG3022-PF
    CG3022-PG
    CG3022-PH
    GABA-B receptor subtype 3
    GABA-B-R3-PA
    GABA-B-R3-PC
    GABA-B-R3-PD
    GABA-B-R3-PE
    GABA-B-R3-PF
    GABA-B-R3-PG
    GABA-B-R3-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      749945..762399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164387.2 → NP_722648.2  metabotropic GABA-B receptor subtype 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722648.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPW4, Q9BML5, Q9VPS7
      Conserved Domains (3) summary
      cd06366
      Location:157 → 590
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:633 → 889
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:174 → 568
      ANF_receptor; Receptor family ligand binding region

    2. NM_001298625.1 → NP_001285554.1  metabotropic GABA-B receptor subtype 3, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPW4, Q9BML5, Q9VPS7
      Conserved Domains (3) summary
      cd06366
      Location:157 → 590
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:633 → 889
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:174 → 568
      ANF_receptor; Receptor family ligand binding region

    3. NM_001258897.1 → NP_001245826.1  metabotropic GABA-B receptor subtype 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245826.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPW4, Q9BML5, Q9VPS7
      Conserved Domains (3) summary
      cd06366
      Location:157 → 590
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:633 → 889
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:174 → 568
      ANF_receptor; Receptor family ligand binding region

    4. NM_001298624.1 → NP_001285553.1  metabotropic GABA-B receptor subtype 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J488
      Conserved Domains (1) summary
      cd06366
      Location:157 → 345
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

    5. NM_001298623.1 → NP_001285552.1  metabotropic GABA-B receptor subtype 3, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285552.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J962
      Conserved Domains (2) summary
      cd06366
      Location:157 → 420
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam01094
      Location:174 → 417
      ANF_receptor; Receptor family ligand binding region

    6. NM_078723.3 → NP_523447.2  metabotropic GABA-B receptor subtype 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523447.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPW4, Q9BML5, Q9VPS7
      Related
      FBpp0077666
      Conserved Domains (3) summary
      cd06366
      Location:157 → 590
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:633 → 889
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:174 → 568
      ANF_receptor; Receptor family ligand binding region

    7. NM_001169375.1 → NP_001162846.1  metabotropic GABA-B receptor subtype 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162846.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q058U9
      Conserved Domains (2) summary
      cd06366
      Location:157 → 590
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam01094
      Location:174 → 568
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q058U9 Q058U9
    Q8MSP9 Q8MSP9
    Q9BML5 Q9BML5
    Q9VPS7 Q9VPS7
    X2J488 X2J488
    X2J962 X2J962

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