ND-B14.5B NADH dehydrogenase (ubiquinone) B14.5 B subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ND-B14.5Bprovided by FlyBase
Official Full Name: NADH dehydrogenase (ubiquinone) B14.5 B subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0031505
Locus tag: Dmel_CG12400
See related: AllianceGenome:FB:FBgn0031505
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE29623; CG12400; Dmel\CG12400; dNDUFC2; N4BM; NDUFC2; Q9VQM2
Summary: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and larval muscle system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to several human genes including NDUFC2 (NADH:ubiquinone oxidoreductase subunit C2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3144953..3145848, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3144953..3145848, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IC Inferred by Curator more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IC Inferred by Curator more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

Names: CG12400-PA; CG12400-PB; NADH ubiquinone oxidoreductase B14.5B; NADH-ubiquinone oxidoreductase subunit B14.5b; NADH:ubiquinone oxidoreductase B14.5B subunit; ND-B14.5B-PA; ND-B14.5B-PB

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The following sections contain reference sequences that belong to a specific genome build. Explain