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    CG5181 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34018, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5181provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031909
    Locus tag
    Dmel_CG5181
    See related
    AllianceGenome:FB:FBgn0031909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CC24; Dmel\CG5181
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; mitotic G2/M transition checkpoint; and response to ionizing radiation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SOSS complex. Orthologous to several human genes including NABP1 (nucleic acid binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5181 in Genome Data Viewer
    Location:
    27F3-27F3; 2-26 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7408533..7409809, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7408533..7409809, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46205 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene chameau

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence of spatially varying selection acting on four chromatin-remodeling loci in Drosophila melanogaster. Levine MT, et al. Genetics, 2008 May. PMID 18245821, Free PMC Article
    2. Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin. Cox RT, et al. Dis Model Mech, 2009 Sep-Oct. PMID 19638420, Free PMC Article
    3. Drosophila domino Exhibits Genetic Interactions with a Wide Spectrum of Chromatin Protein-Encoding Loci. Ellis K, et al. PLoS One, 2015. PMID 26555684, Free PMC Article
    4. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. Barclay SS, et al. Hum Mol Genet, 2014 Mar 1. PMID 24179173
    5. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2/M transition checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ionizing radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SOSS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5181-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7408533..7409809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135271.3 → NP_609115.1  uncharacterized protein Dmel_CG5181 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609115.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VM17
      Related
      FBpp0079091
      Conserved Domains (1) summary
      cd04491
      Location:20 → 97
      SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM17.1 Q9VM17

    Gene LinkOut

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