gcm2 gcm2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gcm2provided by FlyBase
Official Full Name: gcm2provided by FlyBase
Primary source: FLYBASE:FBgn0019809
Locus tag: Dmel_CG3858
See related: AllianceGenome:FB:FBgn0019809
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3858; dGCM2; Dmel\CG3858; FBgn0019809; GCM-2; Gcm2
Summary: Enables DNA-binding transcription factor activity. Involved in several processes, including embryonic crystal cell differentiation; negative regulation of crystal cell differentiation; and neurogenesis. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; embryonic maxillary sensory complex; embryonic ventral epidermis; epithelium; and neuroblasts. Orthologous to human GCM1 (glial cells missing transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9608562..9612706)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9608562..9612706)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gliogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in hemocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasmatocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in plasmatocyte differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info