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    CG10348 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35132, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10348provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032707
    Locus tag
    Dmel_CG10348
    See related
    AllianceGenome:FB:FBgn0032707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10348; lincRNA.186; PRDM16
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal ridge; dorsal ridge primordium; embryonic head epidermis; embryonic/larval posterior spiracle; and head epidermis primordium. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10348 in Genome Data Viewer
    Location:
    37A1-37A2; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18714453..18732524, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18714453..18732524, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Fas-associated factor 2 Neighboring gene Grip71 Neighboring gene Inwardly rectifying potassium channel 3 Neighboring gene long non-coding RNA:CR44768 Neighboring gene long non-coding RNA:CR44769 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila, which lacks canonical transcription-coupled repair proteins, performs transcription-coupled repair. Deger N, et al. J Biol Chem, 2019 Nov 29. PMID 31624146, Free PMC Article
    2. Structural basis for protein recognition by B30.2/SPRY domains. Woo JS, et al. Mol Cell, 2006 Dec 28. PMID 17189197
    3. Transcription factor expression landscape in Drosophila embryonic cell lines. Drewell RA, et al. BMC Genomics, 2024 Mar 23. PMID 38521929, Free PMC Article
    4. A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs. Mohammad F, et al. BMC Syst Biol, 2009 Jan 21. PMID 19154620, Free PMC Article
    5. A survey of the trans-regulatory landscape for Drosophila melanogaster abdominal pigmentation. Rogers WA, et al. Dev Biol, 2014 Jan 15. PMID 24269556

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10348-PB
    CG10348-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18714453..18732524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299130.1 → NP_001286059.1  uncharacterized protein Dmel_CG10348, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V722, Q9VJ55
      Conserved Domains (4) summary
      COG5048
      Location:300 → 363
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:313 → 333
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:311 → 333
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:325 → 349
      zf-H2C2_2; Zinc-finger double domain

    2. NM_136060.3 → NP_609904.2  uncharacterized protein Dmel_CG10348, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609904.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V722, Q9VJ55
      Conserved Domains (4) summary
      COG5048
      Location:300 → 363
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:313 → 333
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:311 → 333
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:325 → 349
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ55 Q9VJ55

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