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    CG5550 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36883, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5550provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034160
    Locus tag
    Dmel_CG5550
    See related
    AllianceGenome:FB:FBgn0034160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF57948; AAL48972; Dmel\CG5550; FBpp0086184
    Summary
    Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in adult heart. Orthologous to several human genes including MFAP4 (microfibril associated protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5550 in Genome Data Viewer
    Location:
    53D10-53D10; 2-80 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16816589..16817577)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12704094..12705082)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44379 Neighboring gene long non-coding RNA:CR44380 Neighboring gene long non-coding RNA:CR43417 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the fibrinogen-like domain of fibrinogen-related proteins in the mosquito, Anopheles gambiae, and the fruitfly, Drosophila melanogaster, genomes. Wang X, et al. BMC Genomics, 2005 Sep 8. PMID 16150145, Free PMC Article
    2. Evolution and potential function of fibrinogen-like domains across twelve Drosophila species. Middha S, et al. BMC Genomics, 2008 May 30. PMID 18513432, Free PMC Article
    3. Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats. Jiao B, et al. Hum Mol Genet, 2021 May 29. PMID 33749734
    4. An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replication. Huang Z, et al. J Virol, 2013 Apr. PMID 23365449, Free PMC Article
    5. CHD1 contributes to intestinal resistance against infection by P. aeruginosa in Drosophila melanogaster. Sebald J, et al. PLoS One, 2012. PMID 22912810, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5550-PA
    CG5550-PB
    Fibrinogen-like
    Fibrinogen-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16816589..16817577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259447.2 → NP_001246376.1  uncharacterized protein Dmel_CG5550, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246376.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7T3
      Conserved Domains (1) summary
      cd00087
      Location:34 → 250
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    2. NM_137316.4 → NP_611160.2  uncharacterized protein Dmel_CG5550, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611160.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAJ8, Q8SYS3
      Related
      FBpp0086184
      Conserved Domains (1) summary
      cd00087
      Location:34 → 246
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7T3 A0A0B4K7T3
    A1ZAJ8 A1ZAJ8
    Q8SYS3 Q8SYS3

    Gene LinkOut

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