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    eIF1 eukaryotic translation initiation factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF1provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035423
    Locus tag
    Dmel_CG17737
    See related
    AllianceGenome:FB:FBgn0035423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey272; BcDNA:RE14985; CG17737; dEIF1; Dmel\CG17737; EIF1
    Summary
    Predicted to enable RNA binding activity; ribosomal small subunit binding activity; and translation initiation factor activity. Involved in cellular response to hypoxia. Predicted to be part of eukaryotic 43S preinitiation complex and multi-eIF complex. Is expressed in organism. Orthologous to several human genes including EIF1 (eukaryotic translation initiation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF1 in Genome Data Viewer
    Location:
    63C1-63C1; 3-7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3223341..3224650)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3223341..3224650)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L28 Neighboring gene La-related protein 4B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation. Linsalata AE, et al. EMBO Rep, 2019 Sep. PMID 31347257, Free PMC Article
    2. Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microRNA. Vilmos P, et al. Genetics, 2013 Oct. PMID 23852386, Free PMC Article
    3. Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals. Henriques T, et al. Mol Cell, 2013 Nov 21. PMID 24184211, Free PMC Article
    4. Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection. Yasunaga A, et al. PLoS Pathog, 2014 Feb. PMID 24550726, Free PMC Article
    5. Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR. Vasudevan D, et al. Nat Commun, 2020 Sep 16. PMID 32938929, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in formation of translation preinitiation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic 43S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic 43S preinitiation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of multi-eIF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 1
    Names
    CG17737-PA
    eIF1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3223341..3224650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139535.4 → NP_647792.1  eukaryotic translation initiation factor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647792.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VZS3
      UniProtKB/TrEMBL
      A0A1B2AJV1
      Related
      FBpp0072908
      Conserved Domains (1) summary
      cd11566
      Location:26 → 109
      eIF1_SUI1; Eukaryotic initiation factor 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZS3.1 Q9VZS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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