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    CG7573 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7573provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036153
    Locus tag
    Dmel_CG7573
    See related
    AllianceGenome:FB:FBgn0036153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7573
    Summary
    Predicted to be involved in CAAX-box protein processing. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7573 in Genome Data Viewer
    Location:
    68C2-68C2; 3-36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11311747..11313397)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11304847..11306497)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45404 Neighboring gene Dpt-YFP repressor by overexpression Neighboring gene long non-coding RNA:CR44361 Neighboring gene long non-coding RNA:CR46240

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Type-I prenyl protease function is required in the male germline of Drosophila melanogaster. Adolphsen K, et al. G3 (Bethesda), 2012 Jun. PMID 22690372, Free PMC Article
    2. Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep. Harbison ST, et al. PLoS Genet, 2017 Dec. PMID 29240764, Free PMC Article
    3. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7573-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11311747..11313397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168455.3 → NP_729695.2  uncharacterized protein Dmel_CG7573 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729695.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQF6, Q8MS56
      Related
      FBpp0075901
      Conserved Domains (2) summary
      pfam16491
      Location:62 → 240
      Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices
      cl12018
      Location:320 → 466
      Peptidase_M48; Peptidase family M48
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS56 Q8MS56

    Gene LinkOut

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