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    Gr68a Gustatory receptor 68a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gr68aprovided by FlyBase
    Official Full Name
    Gustatory receptor 68aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0041231
    Locus tag
    Dmel_CG7303
    See related
    AllianceGenome:FB:FBgn0041231
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    68D.1; CG7303; Dmel\CG7303; GR68a; GR68D.1; Gr68D1
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity and taste receptor activity. Involved in male courtship behavior, tapping to detect pheromone and response to pheromone. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in several structures, including adult subesophageal zone; chaeta; gustatory receptor neurons; organism subdivision; and region of integument. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gr68a in Genome Data Viewer
    Location:
    68D4-68D4; 3-36 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11751305..11752474)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11744405..11745574)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sisters unbound Neighboring gene uncharacterized protein Neighboring gene lost and found Neighboring gene Mucin 68D Neighboring gene mir-314 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Measuring Physiological Responses of Drosophila Sensory Neurons to Lipid Pheromones Using Live Calcium Imaging. Shankar S, et al. J Vis Exp, 2016 Apr 29. PMID 27168110, Free PMC Article
    2. Courtship initiation is stimulated by acoustic signals in Drosophila melanogaster. Ejima A, et al. PLoS One, 2008 Sep 19. PMID 18802468, Free PMC Article
    3. Toward a molecular description of pheromone perception. Giarratani L, et al. Neuron, 2003 Sep 11. PMID 12971888
    4. A Drosophila protein specific to pheromone-sensing gustatory hairs delays males' copulation attempts. Park SK, et al. Curr Biol, 2006 Jun 6. PMID 16753571
    5. Pheromone perception and behavior in Drosophila. Amrein H. Curr Opin Neurobiol, 2004 Aug. PMID 15321064

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study constructed a receptor-to-sensillum map of the legs and a receptor-to-neuron map.
      Title: The molecular and cellular basis of taste coding in the legs of Drosophila.
    2. GR68a protein recognizes a female pheromone(s) involved in the second step of the courtship display, which is essential for efficient execution of the entire courtship and timely mating.
      Title: A putative Drosophila pheromone receptor expressed in male-specific taste neurons is required for efficient courtship.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables taste receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables taste receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemosensory behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of taste NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male courtship behavior, tapping to detect pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of taste ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sensory perception of taste NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    gustatory receptor 68a
    Names
    CG7303-PA
    Gr68a-PA
    gustatory receptor 68D.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11751305..11752474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079303.2 → NP_524027.2  gustatory receptor 68a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524027.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTN0
      UniProtKB/TrEMBL
      C9QPG7
      Related
      FBpp0075849, FBtr0076118
      Conserved Domains (1) summary
      pfam08395
      Location:7 → 379
      7tm_7; 7tm Chemosensory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTN0.2 Q9VTN0

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