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    Chs2 Chitin synthase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chs2provided by FlyBase
    Official Full Name
    Chitin synthase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0029091
    Locus tag
    Dmel_CG7464
    See related
    AllianceGenome:FB:FBgn0029091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7464; chitin synthase; ChSA; CS-2; DmCS-2; DmeCHS2; DmeChSA; Dmel\CG7464
    Summary
    Predicted to enable chitin synthase activity. Predicted to be involved in chitin biosynthetic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Chs2 in Genome Data Viewer
    Location:
    79A5-79A5; 3-47 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21962401..21969964)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21955501..21963064)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45757 Neighboring gene pseudo Neighboring gene Delta[1]-pyrroline-5-carboxylate synthase Neighboring gene Actin 79B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stage-specific expression of the chitin synthase DmeChSA and DmeChSB genes during the onset of Drosophila metamorphosis. Gagou ME, et al. Insect Biochem Mol Biol, 2002 Feb. PMID 11755055
    2. Insect chitin synthase cDNA sequence, gene organization and expression. Tellam RL, et al. Eur J Biochem, 2000 Oct. PMID 10998064
    3. Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae. Chen LP, et al. Open Biol, 2016 Apr. PMID 27249340, Free PMC Article
    4. Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. Ostrowski S, et al. Genetics, 2002 May. PMID 12019232, Free PMC Article
    5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitin synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    chitin synthase 2
    Names
    CG7464-PC
    CG7464-PD
    Chs2-PC
    Chs2-PD
    chitin Syn2
    chitin synthase A
    chitin-synthase
    NP_001137997.2
    NP_524209.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21962401..21969964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079485.4 → NP_524209.3  chitin synthase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524209.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZB3, Q9VNW7
      Conserved Domains (2) summary
      cd04190
      Location:546 → 874
      Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin
      cl00456
      Location:903 → 1055
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001144525.2 → NP_001137997.2  chitin synthase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137997.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z099, E1NZB3
      Conserved Domains (2) summary
      cd04190
      Location:545 → 873
      Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin
      cl00456
      Location:902 → 1054
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z099 B7Z099
    Q8WQ83 Q8WQ83
    Q9VNW7 Q9VNW7

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