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    kek6 kekkon 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kek6provided by FlyBase
    Official Full Name
    kekkon 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0039862
    Locus tag
    Dmel_CG1804
    See related
    AllianceGenome:FB:FBgn0039862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1804; Dmel\CG1804; kek-6; Kek-6; Kek6
    Summary
    Enables neurotrophin binding activity and neurotrophin receptor activity. Involved in regulation of synaptic plasticity. Located in type I terminal bouton. Is expressed in adult head; larval central nervous system; larval ventral nerve cord; and lineage NB3-1 primary motor neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kek6 in Genome Data Viewer
    Location:
    100D1-100D1; 3-102 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31622136..31664646)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27447858..27490368)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Medea Neighboring gene microtubule-associated Nat9 Neighboring gene uncharacterized protein Neighboring gene partner of drosha Neighboring gene Zinc finger MYND-type containing 8 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of an inhibitor of the epidermal growth factor receptor, Kekkon1, in dipterans. Derheimer FA, et al. Genetics, 2004 Jan. PMID 15020419, Free PMC Article
    2. Comparative analysis of the Kekkon molecules, related members of the LIG superfamily. MacLaren CM, et al. Dev Genes Evol, 2004 Jul. PMID 15179511
    3. Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. Alvarado D, et al. Genetics, 2004 May. PMID 15166146, Free PMC Article
    4. Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity. Ulian-Benitez S, et al. PLoS Genet, 2017 Aug. PMID 28846707, Free PMC Article
    5. Bioinformatic analysis suggests potential mechanisms underlying parasitoid venom evolution and function. Alvarado G, et al. Genomics, 2020 Mar. PMID 31247332

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neurotrophin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neurotrophin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in type I terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kekkon 6
    Names
    CG1804-PA
    CG1804-PB
    kek6-PA
    kek6-PB
    kekkon-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31622136..31664646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143623.2 → NP_651880.1  kekkon 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9V6
      Related
      FBpp0085182
      Conserved Domains (5) summary
      cd00096
      Location:295 → 367
      Ig; Immunoglobulin domain
      smart00082
      Location:225 → 274
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:71 → 96
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:144 → 186
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:96 → 155
      LRR_8; Leucine rich repeat

    2. NM_001276222.1 → NP_001263151.1  kekkon 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263151.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHL5
      Conserved Domains (5) summary
      cd00096
      Location:295 → 367
      Ig; Immunoglobulin domain
      smart00082
      Location:225 → 274
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:71 → 96
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:144 → 186
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:96 → 155
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHL5 A0A0B4KHL5
    Q9V9V6 Q9V9V6

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