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    ham hamlet [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hamprovided by FlyBase
    Official Full Name
    hamletprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045852
    Locus tag
    Dmel_CG31753
    See related
    AllianceGenome:FB:FBgn0045852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10568; CG15906; CG15907; CG31753; Dmel\CG31753; Ham; HAM_DROME
    Summary
    Enables DNA-binding transcription factor activity. Involved in several processes, including neuroblast fate commitment; regulation of DNA-templated transcription; and regulation of dendrite development. Located in nucleus. Is expressed in several structures, including embryonic dorsal sensory organ precursor cluster; embryonic lateral sensory organ precursor cluster; embryonic ventral sensory organ precursor cluster group; presumptive embryonic/larval peripheral nervous system; and somatic precursor cell. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1LL and myeloid neoplasm. Orthologous to several human genes including MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ham in Genome Data Viewer
    Location:
    37A2-37A4; 2-54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18762874..18792906, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18762874..18792906, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43804 Neighboring gene long non-coding RNA:CR44904 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Grueber WB, et al. Curr Biol, 2003 Apr 15. PMID 12699617
    2. Nociceptive Biology of Molluscs and Arthropods: Evolutionary Clues About Functions and Mechanisms Potentially Related to Pain. Walters ET. Front Physiol, 2018. PMID 30123137, Free PMC Article
    3. Control of multidendritic neuron differentiation in Drosophila: the role of Collier. Crozatier M, et al. Dev Biol, 2008 Mar 1. PMID 18234173
    4. Exercise and/or Cold Exposure Alters the Gene Expression Profile in the Fat Body and Changes the Heart Function in Drosophila. Huang T, et al. Front Endocrinol (Lausanne), 2022. PMID 35418948, Free PMC Article
    5. The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop. Abdusselamoglu MD, et al. Elife, 2019 Jul 22. PMID 31329099, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH
      Title: Physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH.
    2. This study demonistrated that Ham modifies cellular responses to these iteratively used Notch signals in a context-dependent manner, and controls odorant receptor gene choice and ORN axon targeting specificity.
      Title: Chromatin modification of Notch targets in olfactory receptor neuron diversification.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c18791805-18791361 mobile_element_type = transposon:INE-1{}3935

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hamlet
    Names
    CG31753-PB
    CG31753-PD
    CG31753-PE
    CG31753-PG
    CG31753-PH
    ham-PB
    ham-PD
    ham-PE
    ham-PG
    ham-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18762874..18792906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273614.1 → NP_001260543.1  hamlet, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I7Z8, Q9VJ50, Q9VJ52
      UniProtKB/TrEMBL
      M9PBD2
      Conserved Domains (5) summary
      COG5048
      Location:817 → 910
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:819 → 839
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:817 → 839
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:831 → 855
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:310 → 388
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_001259152.1 → NP_001246081.1  hamlet, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246081.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I7Z8, Q9VJ50, Q9VJ52
      UniProtKB/TrEMBL
      M9PBD2
      Conserved Domains (5) summary
      COG5048
      Location:817 → 910
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:819 → 839
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:817 → 839
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:831 → 855
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:310 → 388
      zf-C2H2_8; C2H2-type zinc ribbon

    3. NM_001273616.1 → NP_001260545.2  hamlet, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDM9
      Conserved Domains (8) summary
      PTZ00121
      Location:597 → 684
      PTZ00121; MAEBL; Provisional
      COG5048
      Location:891 → 984
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:347 → 435
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:893 → 913
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:131 → 209
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:891 → 913
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:905 → 929
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:359 → 401
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    4. NM_165262.3 → NP_724130.4  hamlet, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (8) summary
      PTZ00121
      Location:641 → 728
      PTZ00121; MAEBL; Provisional
      COG5048
      Location:935 → 1028
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:391 → 479
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:937 → 957
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19201
      Location:131 → 253
      PR-SET_ZFPM; PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins
      pfam00096
      Location:935 → 957
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:949 → 973
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:403 → 445
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    5. NM_001273615.1 → NP_001260544.1  hamlet, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD45
      Conserved Domains (4) summary
      COG5048
      Location:460 → 553
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:462 → 482
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:460 → 482
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:474 → 498
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBD2 M9PBD2
    M9PD45 M9PD45
    M9PDM9 M9PDM9
    Q8I7Z8.1 Q8I7Z8

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