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    Mer Merlin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32979, updated on 9-Dec-2024

    Summary

    Official Symbol
    Merprovided by FlyBase
    Official Full Name
    Merlinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086384
    Locus tag
    Dmel_CG14228
    See related
    AllianceGenome:FB:FBgn0086384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG01543; CG14228; D-Mer; Dmel\CG14228; Dmerlin; Emr2; EMR2; mer; MER; NF2
    Summary
    Predicted to enable actin binding activity and integrin binding activity. Involved in several processes, including R8 cell differentiation; germ cell development; and meiotic nuclear division. Located in several cellular components, including Nebenkern; apicomedial cortex; and subapical part of cell. Part of Kibra-Ex-Mer complex. Is active in cytoplasmic side of apical plasma membrane. Colocalizes with cell-cell junction. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Mer in Genome Data Viewer
    Location:
    18E1-18E1; 1-64 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19689697..19693500, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19583730..19587533, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquilin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cell division cycle 42 Neighboring gene Threonyl-carbamoyl synthesis 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in R8 cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in R8 cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell signaling IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in compound eye photoreceptor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endocytic recycling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endocytosis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pole plasm mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cell growth IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of compound eye retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gliogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of organelle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Kibra-Ex-Mer complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Kibra-Ex-Mer complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in Nebenkern IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apicomedial cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in subapical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    merlin
    Names
    BG01543
    CG14228-PA
    CG14228-PB
    D merlin
    Ezrin-moesin-radixin-2
    Mer-PA
    Mer-PB
    Merlin/Neurofibromin 2
    dmerlin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19689697..19693500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298529.1NP_001285458.1  merlin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285458.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24054, Q24564, Q8SWY3
      UniProtKB/TrEMBL
      C6TP59, X2JFU0
      Conserved Domains (3) summary
      smart00295
      Location:14216
      B41; Band 4.1 homologues
      cd13194
      Location:210306
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:341635
      ERM; Ezrin/radixin/moesin family
    2. NM_078689.4NP_523413.1  merlin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24054, Q24564, Q8SWY3
      UniProtKB/TrEMBL
      C6TP59, X2JFU0
      Related
      FBpp0074523
      Conserved Domains (3) summary
      smart00295
      Location:14216
      B41; Band 4.1 homologues
      cd13194
      Location:210306
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:341635
      ERM; Ezrin/radixin/moesin family