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    CG42724 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42724provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261641
    Locus tag
    Dmel_CG42724
    See related
    AllianceGenome:FB:FBgn0261641
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15187; CG31367; CG33097; Dmel\CG42724
    Old locus tag
    Dmel_CG31367; Dmel_CG33097
    Summary
    Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including CNS glial cell; ganglia; head epidermis primordium; mesoderm; and sensory nervous system primordium. Orthologous to several human genes including TCERG1 (transcription elongation regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42724 in Genome Data Viewer
    Location:
    83E4-83E4; 3-47.5 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6361672..6368288, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2187394..2194010, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Hormone receptor 83 Neighboring gene p21-activated kinase Neighboring gene uncharacterized protein Neighboring gene Carnitine O-Acetyl-Transferase Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila. Pons M, et al. Acta Neuropathol Commun, 2018 Dec 12. PMID 30541625, Free PMC Article
    2. Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Blard O, et al. Hum Mol Genet, 2007 Mar 1. PMID 17309878
    3. On the role of PDZ domain-encoding genes in Drosophila border cell migration. Aranjuez G, et al. G3 (Bethesda), 2012 Nov. PMID 23173089, Free PMC Article
    4. Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome. Grimberg KB, et al. Mol Cell Biol, 2011 Feb. PMID 21149573, Free PMC Article
    5. Genomic analysis of heat-shock factor targets in Drosophila. Birch-Machin I, et al. Genome Biol, 2005. PMID 15998452, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c6365672-6365429 mobile_element_type = transposon:R1A1{}5828

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42724-PC
    CG42724-PE
    CG42724-PG
    CG42724-PI
    CG42724-PK
    CG42724-PL
    CG42724-PM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6361672..6368288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202255.1 → NP_001189184.1  uncharacterized protein Dmel_CG42724, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFB8
      Conserved Domains (6) summary
      smart00441
      Location:983 → 1036
      FF; Contains two conserved F residues
      smart00456
      Location:112 → 144
      WW; Domain with 2 conserved Trp (W) residues
      pfam04554
      Location:180 → 243
      Extensin_2; Extensin-like region
      pfam00397
      Location:441 → 468
      WW; WW domain
      pfam01846
      Location:590 → 634
      FF; FF domain
      cl13463
      Location:871 → 935
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    2. NM_001275385.1 → NP_001262314.1  uncharacterized protein Dmel_CG42724, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFB8
      Conserved Domains (6) summary
      smart00441
      Location:983 → 1036
      FF; Contains two conserved F residues
      smart00456
      Location:112 → 144
      WW; Domain with 2 conserved Trp (W) residues
      pfam04554
      Location:180 → 243
      Extensin_2; Extensin-like region
      pfam00397
      Location:441 → 468
      WW; WW domain
      pfam01846
      Location:590 → 634
      FF; FF domain
      cl13463
      Location:871 → 935
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    3. NM_001202257.3 → NP_001189186.1  uncharacterized protein Dmel_CG42724, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189186.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0R8, Q9VI14
      Conserved Domains (4) summary
      smart00456
      Location:112 → 144
      WW; Domain with 2 conserved Trp (W) residues
      COG5104
      Location:442 → 740
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:441 → 468
      WW; WW domain
      pfam01846
      Location:590 → 634
      FF; FF domain

    4. NM_001300264.1 → NP_001287193.1  uncharacterized protein Dmel_CG42724, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0R8, Q9VI14
      Conserved Domains (4) summary
      smart00456
      Location:112 → 144
      WW; Domain with 2 conserved Trp (W) residues
      COG5104
      Location:442 → 740
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:441 → 468
      WW; WW domain
      pfam01846
      Location:590 → 634
      FF; FF domain

    5. NM_001300265.1 → NP_001287194.1  uncharacterized protein Dmel_CG42724, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287194.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGR1
      Conserved Domains (3) summary
      smart00456
      Location:112 → 144
      WW; Domain with 2 conserved Trp (W) residues
      COG5104
      Location:442 → 719
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:295 → 322
      WW; WW domain

    6. NM_176408.2 → NP_788585.1  uncharacterized protein Dmel_CG42724, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0R8, Q9VI14
      Conserved Domains (4) summary
      smart00456
      Location:112 → 144
      WW; Domain with 2 conserved Trp (W) residues
      COG5104
      Location:442 → 740
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:441 → 468
      WW; WW domain
      pfam01846
      Location:590 → 634
      FF; FF domain

    7. NM_001043218.3 → NP_001036683.1  uncharacterized protein Dmel_CG42724, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN86
      Conserved Domains (3) summary
      smart00456
      Location:112 → 144
      WW; Domain with 2 conserved Trp (W) residues
      pfam00397
      Location:441 → 468
      WW; WW domain
      pfam01846
      Location:590 → 634
      FF; FF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFB8 A0A0B4KFB8
    A0A0B4LGR1 A0A0B4LGR1
    Q6NN86 Q6NN86
    Q95U01 Q95U01
    Q9VI14 Q9VI14

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