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    CG8839 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36340, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG8839provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033717
    Locus tag
    Dmel_CG8839
    See related
    AllianceGenome:FB:FBgn0033717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8839
    Summary
    Predicted to enable fatty acid amide hydrolase activity and monoacylglycerol lipase activity. Predicted to be involved in fatty acid catabolic process. Located in cytoplasm and endomembrane system. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic hindgut; and epithelium. Orthologous to human FAAH2 (fatty acid amide hydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8839 in Genome Data Viewer
    Location:
    48F10-48F11; 2-66 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12339610..12344617, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8227115..8232122, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Deneddylase 1 Neighboring gene anastral spindle 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cannabinoid receptors are absent in insects. McPartland J, et al. J Comp Neurol, 2001 Aug 6. PMID 11447587
    2. Evolutionary origins of the endocannabinoid system. McPartland JM, et al. Gene, 2006 Mar 29. PMID 16434153
    3. Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster. Jacobs JA, et al. Cell Rep, 2020 Jun 2. PMID 32492422, Free PMC Article
    4. PINK1 and Parkin regulate IP(3)R-mediated ER calcium release. Ham SJ, et al. Nat Commun, 2023 Aug 25. PMID 37626046, Free PMC Article
    5. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty acid amide hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monoacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8839-PA
    CG8839-PC
    CG8839-PD
    CG8839-PE
    NP_610764.1
    NP_725137.1
    NP_725138.1
    NP_725139.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12339610..12344617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136920.3 → NP_610764.1  uncharacterized protein Dmel_CG8839, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610764.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2E1
      Related
      FBpp0087068
      Conserved Domains (2) summary
      COG0154
      Location:42 → 525
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]
      PRK07488
      Location:49 → 520
      PRK07488; indole acetimide hydrolase; Validated

    2. NM_165884.3 → NP_725137.1  uncharacterized protein Dmel_CG8839, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2E1
      Related
      FBpp0087071
      Conserved Domains (2) summary
      COG0154
      Location:42 → 525
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]
      PRK07488
      Location:49 → 520
      PRK07488; indole acetimide hydrolase; Validated

    3. NM_165885.3 → NP_725138.1  uncharacterized protein Dmel_CG8839, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2E1
      Related
      FBpp0087070
      Conserved Domains (2) summary
      COG0154
      Location:42 → 525
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]
      PRK07488
      Location:49 → 520
      PRK07488; indole acetimide hydrolase; Validated

    4. NM_165886.3 → NP_725139.1  uncharacterized protein Dmel_CG8839, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725139.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2E1
      Related
      FBpp0087069
      Conserved Domains (2) summary
      COG0154
      Location:42 → 525
      GatA; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase [Translation, ribosomal structure and biogenesis]
      PRK07488
      Location:49 → 520
      PRK07488; indole acetimide hydrolase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K2E1 Q7K2E1

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