cN-IIIB cytosolic 5'-nucleotidase IIIB [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cN-IIIBprovided by FlyBase
Official Full Name: cytosolic 5'-nucleotidase IIIBprovided by FlyBase
Primary source: FLYBASE:FBgn0034988
Locus tag: Dmel_CG3362
See related: AllianceGenome:FB:FBgn0034988
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 16769374; CG3362; cNIII-like; Dmel\CG3362
Summary: Enables 5'-nucleotidase activity. Involved in guanosine-containing compound catabolic process and ribonucleoside monophosphate catabolic process. Located in cytosol. Is expressed in adult head. Orthologous to several human genes including NT5C3B (5'-nucleotidase, cytosolic IIIB). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24195498..24197027)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20083021..20084550)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP as a substrate.
Title: Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP.
analysis of Drosophila and human 7-methyl GMP-specific nucleotidases
Title: Identification of Drosophila and human 7-methyl GMP-specific nucleotidases.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5'-nucleotidase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in guanosine-containing compound catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ribonucleoside monophosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_611895.1

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The following sections contain reference sequences that belong to a specific genome build. Explain