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    Smyd4-4 SET and MYND domain containing, class 4, member 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smyd4-4provided by FlyBase
    Official Full Name
    SET and MYND domain containing, class 4, member 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0027495
    Locus tag
    Dmel_CG8378
    See related
    AllianceGenome:FB:FBgn0027495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD29892; CG8378; Dmel\CG8378
    Summary
    Predicted to enable histone H3K4 methyltransferase activity and histone deacetylase binding activity. Involved in compound eye photoreceptor development. Located in cytoplasm and nucleus. Is expressed in embryonic/larval gut; larval central nervous system; larval somatic muscle cell; midgut primordium; and procephalic segment. Orthologous to human SMYD4 (SET and MYND domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Smyd4-4 in Genome Data Viewer
    Location:
    48E2-48E2; 2-66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12140631..12143272)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8028136..8030777)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene jelly belly Neighboring gene uncharacterized protein Neighboring gene SKP1-related B Neighboring gene Organic solute carrier partner 1 Neighboring gene Hen1 methyltransferase Neighboring gene back seat driver Neighboring gene uncharacterized protein Neighboring gene pre-mRNA processing factor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
    2. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
    3. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
    4. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article
    5. Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations. Mateo L, et al. Sci Rep, 2018 Nov 1. PMID 30385770, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone deacetylase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SET and MYND domain containing, class 4, member 4
    Names
    CG8378-PA
    Smyd4-4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12140631..12143272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136886.3 → NP_610730.1  SET and MYND domain containing, class 4, member 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0CP31, Q7KMH5
      Related
      FBpp0087091
      Conserved Domains (3) summary
      pfam00856
      Location:363 → 463
      SET; SET domain
      pfam01753
      Location:230 → 270
      zf-MYND; MYND finger
      pfam13414
      Location:67 → 138
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KMH5 Q7KMH5

    Gene LinkOut

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