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    Paris Parkin Interacting Substrate [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33657, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Parisprovided by FlyBase
    Official Full Name
    Parkin Interacting Substrateprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031610
    Locus tag
    Dmel_CG15436
    See related
    AllianceGenome:FB:FBgn0031610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15436; Dmel\CG15436; dPARIS
    Summary
    Enables DNA binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of mitochondrial fission. Predicted to be located in nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Paris in Genome Data Viewer
    Location:
    24F3-24F4; 2-12 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4463611..4465075)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4463611..4465075)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene uncharacterized protein Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene inebriated Neighboring gene dumpy Neighboring gene Heterochromatin protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identifying potential PARIS homologs in D. melanogaster. Merzetti EM, et al. Genet Mol Res, 2016 Nov 3. PMID 27819722
    2. PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency. Pirooznia SK, et al. Mol Neurodegener, 2020 Mar 5. PMID 32138754, Free PMC Article
    3. Global analysis of target genes of 21 members of the ZAD transcription factor family in Drosophila melanogaster. Krystel J, et al. Gene, 2013 Jan 10. PMID 23085320, Free PMC Article
    4. A small genomic region containing several loci required for gastrulation in Drosophila. Mathew SJ, et al. PLoS One, 2009 Oct 13. PMID 19823683, Free PMC Article
    5. The Recent De Novo Origin of Protein C-Termini. Andreatta ME, et al. Genome Biol Evol, 2015 May 21. PMID 26002864, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    parkin interacting substrate
    Names
    CG15436-PA
    Paris-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4463611..4465075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134996.4 → NP_608840.1  parkin interacting substrate [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608840.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960V8, Q9VR05
      Related
      FBpp0077132
      Conserved Domains (4) summary
      COG5048
      Location:180 → 341
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:212 → 232
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam07776
      Location:4 → 78
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:197 → 219
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR05.2 Q9VR05

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