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    Pxt Peroxinectin-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pxtprovided by FlyBase
    Official Full Name
    Peroxinectin-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261987
    Locus tag
    Dmel_CG7660
    See related
    AllianceGenome:FB:FBgn0261987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.128; CG7660; Dmel\CG7660; Dpxt; pxd; pxt
    Summary
    Predicted to enable peroxidase activity. Involved in chorion-containing eggshell formation and prostaglandin biosynthetic process. Located in extracellular space. Is expressed in several structures, including adult head; egg chamber; germline cell; and somatic cell of ovariole. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pxt in Genome Data Viewer
    Location:
    90C2-90C2; 3-61 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17719454..17722955)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13545176..13548677)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene osa Neighboring gene long non-coding RNA:CR46036 Neighboring gene long non-coding RNA:CR46035 Neighboring gene Autophagy-related 8b Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling. Groen CM, et al. Mol Biol Cell, 2012 Dec. PMID 23051736, Free PMC Article
    2. Prostaglandins limit nuclear actin to control nucleolar function during oogenesis. Talbot DE, et al. Front Cell Dev Biol, 2023. PMID 36875757, Free PMC Article
    3. Prostaglandins regulate invasive, collective border cell migration. Fox EF, et al. Mol Biol Cell, 2020 Jul 15. PMID 32432969, Free PMC Article
    4. What is in a model? Kang DS, et al. Arch Insect Biochem Physiol, 2023 Jan. PMID 36164283
    5. Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation. Tootle TL, et al. Development, 2008 Mar. PMID 18216169, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in pxt, encoding a putative Drosophila cyclooxygenase, cause many transcripts to begin expression prematurely, and are associated with eggshell defects.
      Title: Drosophila eggshell production: identification of new genes and coordination by Pxt.
    2. Drosophila ovarian follicle maturation requires cyclooxygenase-like activity, supplied by peroxidase PXT.
      Title: Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation.
    3. Dpxt function is restricted to the early stages of fly development
      Title: A new peroxinectin-like gene preferentially expressed during oogenesis and early embryogenesis in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chorion-containing eggshell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg chorion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hydrogen peroxide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in prostaglandin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Peroxinectin-like
    Names
    CG7660-PB
    Pxt-PB
    pxd
    pxt
    NP_650648.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17719454..17722955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142391.5 → NP_650648.3  Peroxinectin-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650648.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN93, Q8MRH7, Q9NBX0, Q9VEG6
      Related
      FBpp0082932
      Conserved Domains (3) summary
      cd09823
      Location:396 → 767
      peroxinectin_like; peroxinectin_like animal heme peroxidases
      pfam03098
      Location:237 → 772
      An_peroxidase; Animal haem peroxidase
      cl02511
      Location:67 → 119
      GH64-TLP-SF; glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEG6.3 Q9VEG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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