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    Nasp Nuclear autoantigenic sperm protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41045, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naspprovided by FlyBase
    Official Full Name
    Nuclear autoantigenic sperm proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037624
    Locus tag
    Dmel_CG8223
    See related
    AllianceGenome:FB:FBgn0037624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8223; Dmel\CG8223; FBgn0037624; NASP
    Summary
    Enables histone chaperone activity. Involved in protein stabilization. Is active in nucleus. Is expressed in several structures, including adult head; anterior endoderm anlage; central brain primordium; ganglia; and mesoderm. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nasp in Genome Data Viewer
    Location:
    85A10-85A10; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8747798..8754104)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4573520..4579826)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44228 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo. Tirgar R, et al. PLoS Genet, 2023 Mar. PMID 36930688, Free PMC Article
    2. PFTAIRE Kinase L63 Interactor 1A (Pif1A Protein) Is Required for Actin Cone Movement during Spermatid Individualization in Drosophila melanogaster. Pravder HD, et al. Int J Mol Sci, 2022 Mar 10. PMID 35328431, Free PMC Article
    3. Identification of genes functionally involved in the detrimental effects of mutant histone H3.3-K27M in Drosophila melanogaster. Berlandi J, et al. Neuro Oncol, 2019 May 6. PMID 30715493, Free PMC Article
    4. Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Lee SY, et al. Cell Mol Life Sci, 2014 Jul. PMID 24292889, Free PMC Article
    5. Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Greene JC, et al. Hum Mol Genet, 2005 Mar 15. PMID 15689351

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone chaperone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear autoantigenic sperm protein
    Names
    CG8223-PA
    CG8223-PB
    Nasp-PA
    Nasp-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8747798..8754104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260064.2 → NP_001246993.1  nuclear autoantigenic sperm protein, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A126BEE6, Q9I7K6
      Conserved Domains (2) summary
      sd00006
      Location:283 → 313
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:281 → 352
      TPR_12; Tetratricopeptide repeat

    2. NM_141571.5 → NP_649828.1  nuclear autoantigenic sperm protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649828.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A126BEE6, Q9I7K6
      Related
      FBpp0081398
      Conserved Domains (2) summary
      sd00006
      Location:283 → 313
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:281 → 352
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126BEE6 A0A126BEE6
    Q9I7K6.1 Q9I7K6

    Gene LinkOut

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