Pcbp4 poly(rC) binding protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcbp4provided by RGD
Official Full Name: poly(rC) binding protein 4provided by RGD
Primary source: RGD:1307910
See related: EnsemblRapid:ENSRNOG00000012406 AllianceGenome:RGD:1307910
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in intracellular signal transduction and regulation of RNA metabolic process. Predicted to act upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and regulation of mRNA stability. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human PCBP4 (poly(rC) binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 194.0), Kidney (RPKM 120.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (115971751..115981987)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (107092688..107103276)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (115154848..115165706)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: poly(rC)-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191883.1 → NP_001178812.1 poly(rC)-binding protein 4

See identical proteins and their annotated locations for NP_001178812.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5ZYH1, D3ZCS3

Related

ENSRNOP00000084106.2, ENSRNOT00000103224.2

Conserved Domains (3) summary

cd22517
Location:17 → 86

KH-I_PCBP4_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 4 (PCBP4) and similar proteins

cd22520
Location:101 → 172

KH-I_PCBP4_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 4 (PCBP4) and similar proteins

cd22523
Location:241 → 308

KH-I_PCBP4_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 4 (PCBP4) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

115971751..115981987

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265818.1 → XP_063121888.1 poly(rC)-binding protein 4 isoform X2
XM_006243803.5 → XP_006243865.1 poly(rC)-binding protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I6A961

Conserved Domains (1) summary

cl00098
Location:101 → 172

KH-I; K homology (KH) RNA-binding domain, type I