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    Slfn5 schlafen family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slfn5provided by RGD
    Official Full Name
    schlafen family member 5provided by RGD
    Primary source
    RGD:1312025
    See related
    EnsemblRapid:ENSRNOG00000021719 AllianceGenome:RGD:1312025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity. Predicted to be located in nucleus. Orthologous to human SLFN5 (schlafen family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 462.8), Lung (RPKM 412.7) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slfn5 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68378440..68392515)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67881068..67895013)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70298094..70312062)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 8 Neighboring gene notchless homolog 1 Neighboring gene unc-45 myosin chaperone B Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene large ribosomal subunit protein uL18-like Neighboring gene schlafen family member 9 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization of the Schlafen protein family. Neumann B, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18355440

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    schlafen family member 5
    Names
    schlafen 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430188.1 → NP_001417117.1  schlafen family member 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A096MK60

    2. NM_001430189.1 → NP_001417118.1  schlafen family member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHF6, A6HHF7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      68378440..68392515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270130.1 → XP_063126200.1  schlafen family member 5

      Related
      ENSRNOP00000068390.3, ENSRNOT00000076445.4

    2. XM_220775.9 → XP_220775.3  schlafen family member 5

      See identical proteins and their annotated locations for XP_220775.3

      UniProtKB/TrEMBL
      A0A096MK60
      Related
      ENSRNOP00000037767.8, ENSRNOT00000035730.8
      Conserved Domains (4) summary
      PHA02782
      Location:36 → 327
      PHA02782; hypothetical protein; Provisional
      pfam04326
      Location:187 → 295
      AlbA_2; Putative DNA-binding domain
      cl21455
      Location:569 → 668
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl22977
      Location:832 → 880
      UvrD_C_2; UvrD-like helicase C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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