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    Dcxr dicarbonyl and L-xylulose reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171408, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dcxrprovided by RGD
    Official Full Name
    dicarbonyl and L-xylulose reductaseprovided by RGD
    Primary source
    RGD:620031
    See related
    EnsemblRapid:ENSRNOG00000081885 AllianceGenome:RGD:620031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    glb
    Summary
    Enables L-xylulose reductase (NADPH) activity. Involved in glucose metabolic process and xylulose metabolic process. Predicted to be located in several cellular components, including brush border; cytoplasmic microtubule; and microvillus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 680.0), Liver (RPKM 409.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcxr in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106504730..106506619, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106006404..106008293, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109906119..109909696, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L36a-like Neighboring gene leucine rich repeat containing 45 Neighboring gene Rac family small GTPase 3 Neighboring gene carbonyl reductase 2 Neighboring gene transfer RNA glycine (anticodon ACC) 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of amino acid residues involved in substrate recognition of L-xylulose reductase by site-directed mutagenesis. Ishikura S, et al. Chem Biol Interact, 2003 Feb 1. PMID 12604240
    2. Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney. Nakagawa J, et al. J Biol Chem, 2002 May 17. PMID 11882650
    3. Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells. Matsunaga T, et al. Chem Biol Interact, 2009 Sep 14. PMID 19442656
    4. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
    5. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dcxr is highly expressed in kidney and liver (dicarbonyl/L-xylulose reductase)
      Title: Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-xylulose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-xylulose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-xylulose reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xylulose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xylulose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within xylulose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xylulose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-xylulose reductase
    Names
    XR
    diacetyl/L-xylulose reductase
    dicarbonyl L-xylulose reductase
    NP_599214.1
    XP_038941084.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134387.2 → NP_599214.1  L-xylulose reductase

      See identical proteins and their annotated locations for NP_599214.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q920P0
      UniProtKB/TrEMBL
      A6HLI7, A6HLI8
      Related
      ENSRNOP00000108490.1, ENSRNOT00000168618.1
      Conserved Domains (1) summary
      cd05351
      Location:1 → 243
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106504730..106506619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085156.2 → XP_038941084.1  L-xylulose reductase isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:1 → 122
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920P0.1 GenPept UniProtKB/Swiss-Prot:Q920P0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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