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    Sapcd2 suppressor APC domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680531, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sapcd2provided by RGD
    Official Full Name
    suppressor APC domain containing 2provided by RGD
    Primary source
    RGD:1590629
    See related
    EnsemblRapid:ENSRNOG00000013069 AllianceGenome:RGD:1590629
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including establishment of mitotic spindle orientation; negative regulation of protein localization to cell cortex; and regulation of establishment of planar polarity. Predicted to be located in several cellular components, including apical cortex; apical junction complex; and nuclear lumen. Orthologous to human SAPCD2 (suppressor APC domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 37.0), Spleen (RPKM 13.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sapcd2 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28583615..28590694)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8186089..8195119)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2590355..2597283)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene dipeptidylpeptidase 7 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene neural proliferation, differentiation and control, 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of p42.3 promotes cell growth and tumorigenicity in hepatocellular carcinoma. Sun W, et al. World J Gastroenterol, 2013 May 21. PMID 23704824, Free PMC Article
    2. p42.3: a promising biomarker for the progression and prognosis of human colorectal cancer. Yuan XS, et al. J Cancer Res Clin Oncol, 2013 Jul. PMID 23576022
    3. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Chiu CWN, et al. Dev Cell, 2016 Jan 11. PMID 26766442
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of establishment of planar polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in symmetric cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    suppressor APC domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109418.2 → NP_001102888.1  suppressor APC domain-containing protein 2

      See identical proteins and their annotated locations for NP_001102888.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158701
      UniProtKB/TrEMBL
      A0A8I6AIH9, B0BN66, F7EPX4
      Related
      ENSRNOP00000017466.2, ENSRNOT00000017466.5
      Conserved Domains (1) summary
      pfam11414
      Location:224 → 305
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28583615..28590694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761607.4 → XP_008759829.1  suppressor APC domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIH9
      Conserved Domains (1) summary
      pfam11414
      Location:257 → 338
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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