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    Phactr3 phosphatase and actin regulator 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362284, updated on 9-Dec-2024

    Summary

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    Symbol
    Phactr3provided by RGD
    Full Name
    phosphatase and actin regulator 3provided by RGD
    Primary source
    RGD:1303029
    See related
    EnsemblRapid:ENSRNOG00000057996 AllianceGenome:RGD:1303029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Scapin1; scapinin
    Summary
    Enables actin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in nucleoplasm. Orthologous to human PHACTR3 (phosphatase and actin regulator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 289.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phactr3 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (185582134..185801404)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (165205247..165423692)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (173798542..173871386)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7, pseudogene 15 Neighboring gene ribosomal protein L7a, pseudogene 1 Neighboring gene 60S ribosomal protein L19-like Neighboring gene synaptonemal complex protein 2 Neighboring gene aldo-keto reductase family 1, member B1 (aldose reductase), pseudogene 3 Neighboring gene protein phosphatase 1, regulatory subunit 3D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain. Miyata T, et al. Biochem Biophys Res Commun, 2020 Jul 23. PMID 32423795
    2. Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm. Farghaian H, et al. J Biol Chem, 2011 Jun 3. PMID 21487013, Free PMC Article
    3. Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure. Sagara J, et al. J Biol Chem, 2003 Nov 14. PMID 12925532
    4. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Allen PB, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15107502, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
      Title: Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
    2. Because its expression is highest in relatively plastic regions of the adult brain (cortex, hippocampus), scapinin is a new regulator of neurite outgrowth and neuroplasticity in the brain.
      Title: Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase and actin regulator 3
    Names
    scaffold-associated PP1-inhibiting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434389.1 → NP_001421318.1  phosphatase and actin regulator 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K018, A0A0G2K0S0

    2. NM_001434390.1 → NP_001421319.1  phosphatase and actin regulator 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K018, A0A8I6G2L2

    3. NM_214459.4 → NP_999624.1  phosphatase and actin regulator 3 isoform 3

      See identical proteins and their annotated locations for NP_999624.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6RFY2
      UniProtKB/TrEMBL
      A0A0G2K018, A6KMF0
      Conserved Domains (2) summary
      smart00707
      Location:398 → 422
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam17380
      Location:352 → 505
      DUF5401; Family of unknown function (DUF5401)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      185582134..185801404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284233.1 → XP_063140303.1  phosphatase and actin regulator 3 isoform X3

      UniProtKB/Swiss-Prot
      Q6RFY2
      UniProtKB/TrEMBL
      A0A0G2K018, A6KMF0
      Related
      ENSRNOP00000099827.1, ENSRNOT00000137290.1

    2. XM_039105551.2 → XP_038961479.1  phosphatase and actin regulator 3 isoform X2

      Related
      ENSRNOP00000071558.2, ENSRNOT00000081235.3
      Conserved Domains (2) summary
      smart00707
      Location:434 → 458
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam17380
      Location:388 → 541
      DUF5401; Family of unknown function (DUF5401)

    3. XM_039105550.2 → XP_038961478.1  phosphatase and actin regulator 3 isoform X1

      Related
      ENSRNOP00000078324.1, ENSRNOT00000101054.2
      Conserved Domains (2) summary
      smart00707
      Location:439 → 463
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam17380
      Location:393 → 546
      DUF5401; Family of unknown function (DUF5401)

    4. XM_039105552.2 → XP_038961480.1  phosphatase and actin regulator 3 isoform X3

      Conserved Domains (2) summary
      smart00707
      Location:398 → 422
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam17380
      Location:352 → 505
      DUF5401; Family of unknown function (DUF5401)

    5. XM_039105553.2 → XP_038961481.1  phosphatase and actin regulator 3 isoform X3

      UniProtKB/Swiss-Prot
      Q6RFY2
      UniProtKB/TrEMBL
      A0A0G2K018, A6KMF0
      Related
      ENSRNOP00000110411.1, ENSRNOT00000141524.1
      Conserved Domains (2) summary
      smart00707
      Location:398 → 422
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam17380
      Location:352 → 505
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RFY2.1 GenPept UniProtKB/Swiss-Prot:Q6RFY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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