Nuf2 NUF2 component of NDC80 kinetochore complex [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nuf2provided by RGD
Official Full Name: NUF2 component of NDC80 kinetochore complexprovided by RGD
Primary source: RGD:1307952
See related: EnsemblRapid:ENSRNOG00000002711 AllianceGenome:RGD:1307952
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cdca1
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in kinetochore organization; mitotic spindle organization; and nuclear chromosome segregation. Predicted to be located in cytosol; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 181.1), Spleen (RPKM 85.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (84226448..84290957, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (81693675..81722765, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (87818456..87847223, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in kinetochore organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Ndc80 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ndc80 complex	IEA Inferred from Electronic Annotation more info
part_of Ndc80 complex	ISO Inferred from Sequence Orthology more info
part_of Ndc80 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinetochore protein Nuf2

Names: NDC80 kinetochore complex component NUF2; NUF2, NDC80 kinetochore complex component, homolog; cell division cycle associated 1; cell division cycle-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012028.1 → NP_001012028.1 kinetochore protein Nuf2

See identical proteins and their annotated locations for NP_001012028.1

Status: PROVISIONAL

Source sequence(s)

BC078993

UniProtKB/Swiss-Prot

Q6AYL9

UniProtKB/TrEMBL

A0A8I6ACM4

Related

ENSRNOP00000003650.5, ENSRNOT00000003650.8

Conserved Domains (2) summary

COG1340
Location:175 → 443

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

pfam03800
Location:3 → 146

Nuf2; Nuf2 family