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    paaX DNA-binding transcriptional repressor PaaX [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945966, updated on 17-Dec-2024

    Summary

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    Official Symbol
    paaX
    Official Full Name
    DNA-binding transcriptional repressor PaaX
    Primary source
    ECOCYC:G6720
    Locus tag
    b1399
    See related
    ASAP:ABE-0004674
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1396; ydbY
    Summary
    The "phenylacetic acid" regulator , PaaX, is a transcriptional repressor that participates in controlling transcriptional regulation of genes involved in the catabolism of an aromatic compound, phenylacetic acid (PA) . [More information is available at EcoCyc: G6720].
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    Genomic context

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    Sequence:
    NC_000913.3 (1463539..1464489)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene beta-ketoadipyl-CoA thiolase Neighboring gene phenylacetate-CoA ligase Neighboring gene 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA thioesterase Neighboring gene uncharacterized protein YnbG Neighboring gene pseudo Neighboring gene IS2 insertion element protein InsB Neighboring gene IS2 insertion element repressor InsA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coregulation by phenylacetyl-coenzyme A-responsive PaaX integrates control of the upper and lower pathways for catabolism of styrene by Pseudomonas sp. strain Y2. del Peso-Santos T, et al. J Bacteriol, 2006 Jul. PMID 16788190, Free PMC Article
    2. Regulation of penicillin G acylase gene expression in Escherichia coli by repressor PaaX and the cAMP-cAMP receptor protein complex. Kim HS, et al. J Biol Chem, 2004 Aug 6. PMID 15159386
    3. The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system. Leonhartsberger S, et al. J Mol Biol, 2001 Mar 16. PMID 11243806
    4. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
    5. Identification of mutator genes and mutational pathways in Escherichia coli using a multicopy cloning approach. Yang H, et al. Mol Microbiol, 2004 Jul. PMID 15225322

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phenylacetate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor PaaX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1463539..1464489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415917.1 DNA-binding transcriptional repressor PaaX [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415917.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N6WSP4
      Conserved Domains (1) summary
      TIGR02277
      Location:21 → 303
      PaaX_trns_reg; phenylacetic acid degradation operon negative regulatory protein PaaX
    Nucleotide Protein
    Heading Accession and Version

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