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    mdtI multidrug/spermidine efflux pump membrane subunit MdtI [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947333, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mdtI
    Official Full Name
    multidrug/spermidine efflux pump membrane subunit MdtI
    Primary source
    ECOCYC:G6857
    Locus tag
    b1599
    See related
    ASAP:ABE-0005343
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1594; ydgE
    Summary
    MdtI belongs to the SMR efflux pump family, DMT superfamily. [More information is available at EcoGene: EG13926]. MdtI is part of the MdtJI spermidine SMR transporter. [More information is available at EcoCyc: G6857].
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    Genomic context

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    Sequence:
    NC_000913.3 (1672820..1673149, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YdgU Neighboring gene putative serine protease YdgD Neighboring gene multidrug/spermidine efflux pump membrane subunit MdtJ Neighboring gene protein MdtU Neighboring gene autoinducer 2 exporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of novel multidrug transporters from human pathogens. Ninio S, et al. J Biol Chem, 2001 Dec 21. PMID 11574548
    2. Small multidrug resistance proteins: a multidrug transporter family that continues to grow. Bay DC, et al. Biochim Biophys Acta, 2008 Sep. PMID 17942072
    3. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Paulsen IT, et al. Mol Microbiol, 1996 Mar. PMID 8730859
    4. N-acetyl-d-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli. Hirakawa H, et al. J Bacteriol, 2006 Aug. PMID 16885453, Free PMC Article
    5. EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli. Nishino K, et al. J Bacteriol, 2002 Apr. PMID 11914367, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables amino-acid betaine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermidine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables spermidine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermidine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in choline transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine betaine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermidine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermidine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermidine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within spermidine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermidine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of transmembrane transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multidrug/spermidine efflux pump membrane subunit MdtI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1672820..1673149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416116.1 multidrug/spermidine efflux pump membrane subunit MdtI [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416116.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5Y9B6
      Conserved Domains (1) summary
      PRK10650
      Location:1 → 109
      PRK10650; multidrug/spermidine efflux SMR transporter subunit MdtI
    Nucleotide Protein
    Heading Accession and Version

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