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    wzc protein-tyrosine kinase Wzc [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946567, updated on 3-Dec-2024

    Summary

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    Official Symbol
    wzc
    Official Full Name
    protein-tyrosine kinase Wzc
    Primary source
    ECOCYC:G7105
    Locus tag
    b2060
    See related
    ASAP:ABE-0006819
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2054
    Summary
    Wzc, but not Wzc-P, activates colanic acid synthesis, needed for capsule production. [More information is available at EcoGene: EG13568]. Wzc catalyzes autophosphorylation on tyrosine . [More information is available at EcoCyc: G7105].
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    Genomic context

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    Sequence:
    NC_000913.3 (2133490..2135652, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene colanic acid biosynthesis galactosyltransferase WcaC Neighboring gene colanic acid biosynthesis acetyltransferase WcaB Neighboring gene UDP-glucuronate:2-O-Ac-beta-D-Gal-(1->3)-alpha-L-Fuc-(1->4)-2/3-O-Ac-alpha-L-Fuc-(1->3)-beta-D-Glc-PP-Und beta-(1,3)-glucuronosyltransferase Neighboring gene protein-tyrosine phosphatase Neighboring gene outer membrane polysaccharide export protein Wza

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of structural and molecular determinants of the tyrosine-kinase Wzc and implications in capsular polysaccharide export. Bechet E, et al. Mol Microbiol, 2010 Sep. PMID 20633230
    2. The molecular basis of regulation of bacterial capsule assembly by Wzc. Yang Y, et al. Nat Commun, 2021 Jul 16. PMID 34272394, Free PMC Article
    3. Phosphorylation of the integrase protein of coliphage HK022. Kolot M, et al. Virology, 2008 Jun 5. PMID 18353423
    4. Tyrosine-kinase Wzc from Escherichia coli possesses an ATPase activity regulated by autophosphorylation. Soulat D, et al. FEMS Microbiol Lett, 2007 Sep. PMID 17627778
    5. Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules. Collins RF, et al. J Biol Chem, 2006 Jan 27. PMID 16172129, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The molecular basis of regulation of bacterial capsule assembly by Wzc.
      Title: The molecular basis of regulation of bacterial capsule assembly by Wzc.
    2. Mutational analysis demonstrates that a conserved EX(2) RX(2) R motif involved in subunit interactions is essential for polysaccharide export.
      Title: Identification of structural and molecular determinants of the tyrosine-kinase Wzc and implications in capsular polysaccharide export.
    3. Wzc protein-protein contacts form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules
      Title: Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules.
    4. the Wza-Wzc complex provides the structural and regulatory core of a larger macromolecular machine, suggesting a mechanism by which capsular polysaccharides may move from the periplasm through the outer membrane
      Title: The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within colanic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein-tyrosine kinase Wzc

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2133490..2135652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416564.4 protein-tyrosine kinase Wzc [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416564.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G1UG17
      Conserved Domains (1) summary
      PRK11519
      Location:1 → 719
      PRK11519; tyrosine-protein kinase Wzc
    Nucleotide Protein
    Heading Accession and Version

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