U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    alaC glutamate--pyruvate aminotransferase AlaC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946850, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    alaC
    Official Full Name
    glutamate--pyruvate aminotransferase AlaC
    Primary source
    ECOCYC:G7242
    Locus tag
    b2379
    See related
    ASAP:ABE-0007850
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2375; yfdZ
    Summary
    AFMB Structural Genomics target Number 22 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG14198]. Expression of yfdZ is activated by the transcriptional regulator SgrR. [More information is available at EcoCyc: G7242].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2497057..2498295, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene palmitoleoyl acyltransferase Neighboring gene putative membrane protein YpdK Neighboring gene sensor histidine kinase PyrS Neighboring gene DNA-binding transcriptional activator PyrR

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation of a mutant auxotrophic for L-alanine and identification of three major aminotransferases that synthesize L-alanine in Escherichia coli. Yoneyama H, et al. Biosci Biotechnol Biochem, 2011. PMID 21597182
    2. Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli. Peña-Soler E, et al. PLoS One, 2014. PMID 25014014, Free PMC Article
    3. Genetics and regulation of the major enzymes of alanine synthesis in Escherichia coli. Kim SH, et al. J Bacteriol, 2010 Oct. PMID 20729367, Free PMC Article
    4. The novel transcription factor SgrR coordinates the response to glucose-phosphate stress. Vanderpool CK, et al. J Bacteriol, 2007 Mar. PMID 17209026, Free PMC Article
    5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
      Title: Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-alanine:2-oxoglutarate aminotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-alanine:2-oxoglutarate aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-alanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within L-alanine biosynthetic process from pyruvate IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within L-alanine biosynthetic process from pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within alanine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutamate--pyruvate aminotransferase AlaC
    NP_416880.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2497057..2498295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416880.1 glutamate--pyruvate aminotransferase AlaC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416880.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N0IRZ1, A0A793GPF9
      Conserved Domains (1) summary
      PRK08175
      Location:8 → 402
      PRK08175; aminotransferase; Validated
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.