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    dpiA DNA-binding transcriptional dual regulator DpiA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947008, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dpiA
    Official Full Name
    DNA-binding transcriptional dual regulator DpiA
    Primary source
    ECOCYC:G6346
    Locus tag
    b0620
    See related
    ASAP:ABE-0002131
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    citB; criR; ECK0613; mpdA
    Summary
    The DpiA "destabilization of plasmid inheritance," transcriptional regulator is suggested to have roles in multiple cellular processes, such as inducing the expression of genes involved in citrate fermentation, repressing a transcriptional regulator (AppY) , destabilizing plasmid inheritance, and inducing the SOS response by interrupting chromosome replication . [More information is available at EcoCyc: G6346].
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    Genomic context

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    Sequence:
    NC_000913.3 (653862..654542)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene citrate lyase beta subunit Neighboring gene citrate lyase acyl carrier protein Neighboring gene citrate lyase synthetase Neighboring gene sensor histidine kinase DpiB Neighboring gene anaerobic C4-dicarboxylate transporter DcuC Neighboring gene Lipid A palmitoyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro binding of the response regulator CitB and of its carboxy-terminal domain to A + T-rich DNA target sequences in the control region of the divergent citC and citS operons of Klebsiella pneumoniae. Meyer M, et al. J Mol Biol, 1997 Jun 27. PMID 9223636
    2. Identification of a putative pathogenicity island in Shigella flexneri using subtractive hybridisation of the S. flexneri and Escherichia coli genomes. Walker JC, et al. FEMS Microbiol Lett, 2002 Aug 6. PMID 12167547
    3. Identification of a Shigella flexneri criR gene increasing ipa genes expression: a novel member of response regulators of the two-component signal transduction family. Qi MS, et al. Jpn J Med Sci Biol, 1996 Oct-Dec. PMID 9095416
    4. Destabilized inheritance of pSC101 and other Escherichia coli plasmids by DpiA, a novel two-component system regulator. Ingmer H, et al. Mol Microbiol, 1998 Jul. PMID 9701802
    5. The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor. Kaspar S, et al. Arch Microbiol, 2002 Apr. PMID 11889485

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DcuS/DcuR modulating citA and citB expression.
      Title: CitA/CitB two-component system regulating citrate fermentation in Escherichia coli and its relation to the DcuS/DcuR system in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay response regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator DpiA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      653862..654542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415153.1 DNA-binding transcriptional dual regulator DpiA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415153.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8E0FH97
      Conserved Domains (1) summary
      PRK10046
      Location:1 → 225
      dpiA; two-component response regulator DpiA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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