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    crl [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945077, updated on 3-Dec-2024

    Summary

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    Official Symbol
    crl
    Primary source
    ECOCYC:EG11092
    Locus tag
    b0240
    See related
    ASAP:ABE-0000821
    Gene type
    pseudo
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0241
    Summary
    RpoD, RpoS and RpoH sigma factor-containing holoenzyme assembly is stimulated by Crl (Gaal, 2006). [More information is available at EcoGene: EG11092]. Crl regulates the activity and abundance of the RNA polymerase component sigma S. [More information is available at EcoCyc: EG11092].
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    Genomic context

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    Sequence:
    NC_000913.3 (257829..259006)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene xanthine-guanine phsophoribosyltransferase Neighboring gene fermentation-respiration switch protein Neighboring gene IS1 family transposase B Neighboring gene IS1 family repressor TnpA Neighboring gene outer membrane porin PhoE Neighboring gene glutamate 5-kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of crl in avian pathogenic Escherichia coli: a knockout mutation of crl does not affect hemagglutination activity, fibronectin binding, or Curli production. Provence DL, et al. Infect Immun, 1992 Nov. PMID 1398960, Free PMC Article
    2. Newly identified genetic variations in common Escherichia coli MG1655 stock cultures. Freddolino PL, et al. J Bacteriol, 2012 Jan. PMID 22081388, Free PMC Article
    3. Fibronectin binding mediated by a novel class of surface organelles on Escherichia coli. Olsén A, et al. Nature, 1989 Apr 20. PMID 2649795
    4. Crl, a low temperature-induced protein in Escherichia coli that binds directly to the stationary phase sigma subunit of RNA polymerase. Bougdour A, et al. J Biol Chem, 2004 May 7. PMID 14978043
    5. The Crl protein activates cryptic genes for curli formation and fibronectin binding in Escherichia coli HB101. Arnqvist A, et al. Mol Microbiol, 1992 Sep. PMID 1357528

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recently identified mutations that are likely to cause loss of function of the glpR and crl genes, which may have serious implications for physiological experiments using the affected strains, are reported.
      Title: Newly identified genetic variations in common Escherichia coli MG1655 stock cultures.
    2. The csgFG and crl mutants were deficient in their biofilm formation capabilities and did not form a pellicle at the air-liquid interface.
      Title: Biofilm formation by and multicellular behavior of Escherichia coli O55:H7, an atypical enteropathogenic strain.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Fibronectin binding mediated by a novel class of surface organelles on Escherichia coli.
    4. role of Crl in regulating the expression of the proteome
      Title: The Crl-RpoS regulon of Escherichia coli.
    5. Crl has a global regulatory effect in stationary phase gene expression exclusively through sigma(S), that is, on sigma(S)-dependent genes only.
      Title: Stationary phase reorganisation of the Escherichia coli transcription machinery by Crl protein, a fine-tuner of sigmas activity and levels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Miscellaneous features

    • Loc: 257829-257899 gene fragment 1 of crl
    • Loc: 258676-259006 gene fragment 2 of crl

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