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    crr Enzyme IIA(Glc) [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946880, updated on 3-Dec-2024

    Summary

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    Official Symbol
    crr
    Official Full Name
    Enzyme IIA(Glc)
    Primary source
    ECOCYC:EG10165
    Locus tag
    b2417
    See related
    ASAP:ABE-0007971
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2412; gsr; iex; tgs; treD
    Summary
    Phosphorylation of Enzyme IIAGlc is necessary for direct translational control of rpoS. [More information is available at EcoGene: EG10165]. [More information is available at EcoCyc: EG10165].
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    Genomic context

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    Sequence:
    NC_000913.3 (2535834..2536343)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphocarrier protein HPr Neighboring gene PTS enzyme I Neighboring gene pyridoxine/pyridoxal/pyridoxamine kinase Neighboring gene DUF5329 domain-containing protein YfeK

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sugar transport. The crr mutation: its effect on repression of enzyme synthesis. Saier MH Jr, et al. J Biol Chem, 1976 Nov 10. PMID 789369
    2. Effects of detergent alkyl chain length and chemical structure on the properties of a micelle-bound bacterial membrane targeting peptide. Keifer PA, et al. Anal Biochem, 2004 Aug 1. PMID 15245994
    3. Why the phosphotransferase system of Escherichia coli escapes diffusion limitation. Francke C, et al. Biophys J, 2003 Jul. PMID 12829515, Free PMC Article
    4. Solution structure of the N-terminal amphitropic domain of Escherichia coli glucose-specific enzyme IIA in membrane-mimetic micelles. Wang G, et al. Protein Sci, 2003 May. PMID 12717030, Free PMC Article
    5. Effects of mutations and truncations on the kinetic behavior of IIAGlc, a phosphocarrier and regulatory protein of the phosphoenolpyruvate phosphotransferase system of Escherichia coli. Meadow ND, et al. J Biol Chem, 2006 Apr 28. PMID 16439362

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that the phosphoenolpyruvate hexose phosphotransferases PTS network serves as a global sensor of the sugar influx and also monitors the levels of several non-PTS compounds.
      Title: Sugar Influx Sensing by the Phosphotransferase System of Escherichia coli.
    2. results of a detailed investigation of the role of EIIAGlc in CsrB/C decay; unphosphorylated EIIAGlc binds specifically to the EAL domain of CsrD and stimulates CsrB/C turnover
      Title: Regulation of CsrB/C sRNA decay by EIIA(Glc) of the phosphoenolpyruvate: carbohydrate phosphotransferase system.
    3. The data suggest a model of how the central regulatory protein EIIA(Glc) allosterically inhibits maltose uptake in E. coli.
      Title: Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography.
    4. Transport proteins PotD and Crr of Escherichia coli, novel fusion partners for heterologous protein expression.
      Title: Transport proteins PotD and Crr of Escherichia coli, novel fusion partners for heterologous protein expression.
    5. N-terminus verified by Edman degradation on mature peptide
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of carbohydrate metabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of maltose transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of carbohydrate utilization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of enzyme IIA-maltose transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of transmembrane transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Enzyme IIA(Glc)
    NP_416912.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2535834..2536343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416912.1 Enzyme IIA(Glc) [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416912.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FP79
      Conserved Domains (1) summary
      PRK09439
      Location:1 → 169
      PRK09439; PTS system glucose-specific transporter subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version

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