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    dinG ATP-dependent DNA helicase DinG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945431, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dinG
    Official Full Name
    ATP-dependent DNA helicase DinG
    Primary source
    ECOCYC:EG11357
    Locus tag
    b0799
    See related
    ASAP:ABE-0002732
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0788; rarB
    Summary
    dinG is a non-essential gene. [More information is available at EcoGene: EG11357]. DinG exhibits ATP-dependent DNA helicase activity that may play a role in DNA repair and replication . [More information is available at EcoCyc: EG11357].
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    Genomic context

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    Sequence:
    NC_000913.3 (833070..835220)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent RNA helicase RhlE Neighboring gene N-glycosidase YbiA Neighboring gene nonspecific DNA-binding protein YbiB Neighboring gene hydroxycarboxylate dehydrogenase B Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA translocation mechanism of an XPD family helicase. Cheng K, et al. Elife, 2018 Dec 6. PMID 30520735, Free PMC Article
    2. DNA-mediated signaling by proteins with 4Fe-4S clusters is necessary for genomic integrity. Grodick MA, et al. J Am Chem Soc, 2014 Apr 30. PMID 24738733, Free PMC Article
    3. Redox control of the DNA damage-inducible protein DinG helicase activity via its iron-sulfur cluster. Ren B, et al. J Biol Chem, 2009 Feb 20. PMID 19074432, Free PMC Article
    4. The DinG protein from Escherichia coli is a structure-specific helicase. Voloshin ON, et al. J Biol Chem, 2007 Jun 22. PMID 17416902
    5. Interaction of LexA repressor with the asymmetric dinG operator and complete nucleotide sequence of the gene. Lewis LK, et al. J Bacteriol, 1992 Aug. PMID 1629168, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rep and UvrD helicases operate on DNA at the replication fork whereas DinG helicase acts via a different mechanism
      Title: Direct removal of RNA polymerase barriers to replication by accessory replicative helicases.
    2. Here we present crystal structures of complexes of DinG bound to single-stranded DNA (ssDNA) in the presence and absence of an ATP analogue (ADP*BeF3), that suggest a mechanism for 5'-3' translocation along the ssDNA substrate. This proposed mechanism has implications for how those enzymes of the XPD family that recognise bulky DNA lesions might stall at these as the first step in initiating DNA repair
      Title: DNA translocation mechanism of an XPD family helicase.
    3. YbiB from Escherichia coli, the defining member of the novel Trpd2 family of prokaryotic DNA-binding proteins, forms an operon with the DNA helicase gene dinG and is under LexA control.
      Title: YbiB from Escherichia coli, the Defining Member of the Novel TrpD2 Family of Prokaryotic DNA-binding Proteins.
    4. The DNA helicases UvrD and DinG suppress the lethality caused by mutant cspA.
      Title: Identification of two DNA helicases UvrD and DinG as suppressors for lethality caused by mutant cspA mRNAs.
    5. when rRNA operons (rrn) are inverted to face replication, the viability of the dinG mutant is affected and over-expression of RNase H rescues the growth defect, showing that DinG acts in vivo to remove R-loops
      Title: The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo.
    6. DinG protein from Escherichia coli is a structure-specific helicase involved in recombinational DNA repair and the resumption of replication after DNA damage
      Title: The DinG protein from Escherichia coli is a structure-specific helicase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-3' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA/RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA/RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA duplex unwinding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G-quadruplex DNA unwinding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SOS response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within SOS response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase DinG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      833070..835220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415320.1 ATP-dependent DNA helicase DinG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415320.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      C3THT0
      Conserved Domains (1) summary
      PRK11747
      Location:2 → 696
      dinG; ATP-dependent DNA helicase DinG; Provisional
    Nucleotide Protein
    Heading Accession and Version

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