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    endA DNA-specific endonuclease I [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949092, updated on 3-Dec-2024

    Summary

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    Official Symbol
    endA
    Official Full Name
    DNA-specific endonuclease I
    Primary source
    ECOCYC:EG11336
    Locus tag
    b2945
    See related
    ASAP:ABE-0009661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2940
    Summary
    First 22 aa are predicted to be a type I signal peptide. [More information is available at EcoGene: EG11336]. Endonuclease I is a periplasmic enzyme that cleaves within duplex DNA. [More information is available at EcoCyc: EG11336].
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    Genomic context

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    Sequence:
    NC_000913.3 (3090347..3091054)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene galactose:H(+) symporter Neighboring gene protein YggI Neighboring gene 16S rRNA m(3)U1498 methyltransferase Neighboring gene glutathione synthetase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The isolation and characterization from Escherichia coli of an adenosine triphosphate-dependent deoxyribonuclease directed by rec B, C genes. Wright M, et al. J Biol Chem, 1971 Nov. PMID 4332130
    2. The deoxyribonucleases of Escherichia coli. II. Purification and properties of a ribonucleic acid-inhibitable endonuclease. LEHMAN IR, et al. J Biol Chem, 1962 Mar. PMID 14463751
    3. The deoxyribo-nucleases of Escherichia coli. III. Studies on the nature of the inhibition of endonuclease by ribonucleic acid. LEHMAN IR, et al. J Biol Chem, 1962 Mar. PMID 14463750
    4. MECHANISM OF DEGRADATION OF DNA BY ENDONUCLEASE I FROM ESCHERICHIA COLI. BERMARDO G, et al. J Mol Biol, 1965 Jan. PMID 14255756
    5. Escherichia coli endA deletion strain for use in two-hybrid shuttle vector selection. Griffith M, et al. Biotechniques, 2003 Aug. PMID 12951767

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribonuclease I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-specific endonuclease I
    NP_417420.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3090347..3091054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417420.1 DNA-specific endonuclease I [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417420.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A403D4J9
      Conserved Domains (1) summary
      PRK15137
      Location:1 → 235
      PRK15137; DNA-specific endonuclease I; Provisional
    Nucleotide Protein
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