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    hyaC hydrogenase 1 cytochrome b subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945581, updated on 17-Dec-2024

    Summary

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    Official Symbol
    hyaC
    Official Full Name
    hydrogenase 1 cytochrome b subunit
    Primary source
    ECOCYC:EG10470
    Locus tag
    b0974
    See related
    ASAP:ABE-0003290
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cybH; ECK0965
    Summary
    The hyaC gene product is very hydrophobic, rich in aromatic residues, and has four putative hydrophobic membrane-spanning regions . [More information is available at EcoCyc: EG10470].
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    Genomic context

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    Sequence:
    NC_000913.3 (1035066..1035773)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene hydrogenase 1 small subunit Neighboring gene hydrogenase 1 large subunit Neighboring gene putative hydrogenase 1 maturation protease HyaD Neighboring gene putative HyaA chaperone Neighboring gene protein HyaF Neighboring gene cytochrome bd-II subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the O(2)-tolerant membrane-bound hydrogenase 1 from Escherichia coli in complex with its cognate cytochrome b. Volbeda A, et al. Structure, 2013 Jan 8. PMID 23260654
    2. Purification and properties of membrane-bound hydrogenase isoenzyme 1 from anaerobically grown Escherichia coli K12. Sawers RG, et al. Eur J Biochem, 1986 Apr 15. PMID 3516689
    3. Nickel-containing hydrogenase isoenzymes from anaerobically grown Escherichia coli K-12. Ballantine SP, et al. J Bacteriol, 1985 Aug. PMID 3894325, Free PMC Article
    4. Effect of redox potential on activity of hydrogenase 1 and hydrogenase 2 in Escherichia coli. Laurinavichene TV, et al. Arch Microbiol, 2002 Dec. PMID 12420163
    5. Electron paramagnetic resonance (EPR) studies on hydrogenase-1 (HYD1) purified from a mutant strain (AP6) of Escherichia coli enhanced in HYD1. DerVartanian ME, et al. Biochem Biophys Res Commun, 1996 Oct 3. PMID 8858127

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of dimeric membrane-bound O(2)-tolerant hydrogenase 1 from Escherichia coli in a 2:1 complex with its physiological partner, cytochrome b.
      Title: Crystal structure of the O(2)-tolerant membrane-bound hydrogenase 1 from Escherichia coli in complex with its cognate cytochrome b.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrogenase (acceptor) activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anaerobic electron transport chain IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in anaerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaerobic respiration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within anaerobic respiration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fermentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fermentation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen metabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of [Ni-Fe] hydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of [Ni-Fe] hydrogenase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydrogenase 1 cytochrome b subunit
    NP_415493.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1035066..1035773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415493.1 hydrogenase 1 cytochrome b subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415493.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DU59
      Conserved Domains (1) summary
      PRK10171
      Location:1 → 235
      PRK10171; Ni/Fe-hydrogenase b-type cytochrome subunit
    Nucleotide Protein
    Heading Accession and Version

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