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    cpdA cAMP phosphodiesterase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947515, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cpdA
    Official Full Name
    cAMP phosphodiesterase
    Primary source
    ECOCYC:G7579
    Locus tag
    b3032
    See related
    ASAP:ABE-0009957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3023; icc
    Summary
    CpdA is defective in Crooke's strain (ATCC 8739). [More information is available at EcoGene: EG12187]. cAMP phosphodiesterase hydrolyzes the important regulatory molecule cAMP and thus influences the level of transcription of genes regulated by cAMP-CRP. [More information is available at EcoCyc: G7579].
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    Genomic context

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    Sequence:
    NC_000913.3 (3176006..3176833, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase IV subunit B Neighboring gene esterase YqiA Neighboring gene DUF1249 domain-containing protein YqiB Neighboring gene ADP-sugar pyrophosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The enzymic degradation of 3',5' cyclic AMP in strains of E. Coli sensitive and resistant to catobolite repression. Monard D, et al. Biochem Biophys Res Commun, 1969 May 22. PMID 4306958
    2. Cyclic 3';5' adenosine monophosphate-phosphodiesterase and the release of catabolite repression of beta-galactosidase by exogenous cyclic 3';5' adenosine monophosphate in Escherichia coli. Aboud M, et al. Biochem Biophys Res Commun, 1971 Apr 2. PMID 4325494
    3. Cyclic 3',5'-adenosine monophosphate phosphodiesterase of Escherichia coli. Nielsen LD, et al. J Bacteriol, 1973 Nov. PMID 4355491, Free PMC Article
    4. Cyclic AMP phosphodiesterase of Escherichia coli. Nielsen LD, et al. Methods Enzymol, 1974. PMID 4375756
    5. 3',5' Cyclic nucleotide phosphodiesterases class III: members, structure, and catalytic mechanism. Richter W. Proteins, 2002 Feb 15. PMID 11835503

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Identification of the cpdA gene encoding cyclic 3',5'-adenosine monophosphate phosphodiesterase in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cAMP phosphodiesterase
    NP_417504.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3176006..3176833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417504.1 cAMP phosphodiesterase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417504.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H9SDN6
      Conserved Domains (1) summary
      PRK11148
      Location:1 → 275
      PRK11148; cyclic 3',5'-adenosine monophosphate phosphodiesterase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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