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    PHB1 prohibitin subunit PHB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853033, updated on 27-Dec-2024

    Summary

    Official Symbol
    PHB1
    Official Full Name
    prohibitin subunit PHB1
    Primary source
    SGD:S000003364
    Locus tag
    YGR132C
    See related
    AllianceGenome:SGD:S000003364; FungiDB:YGR132C; VEuPathDB:YGR132C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including inner mitochondrial membrane organization; mitochondrion inheritance; and protein folding. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See PHB1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (755589..756452, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Fhn1p Neighboring gene E2 ubiquitin-protein ligase peroxin 4 Neighboring gene CCR4-NOT core subunit CAF130

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in membrane  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  

    General protein information

    Preferred Names
    prohibitin subunit PHB1
    NP_011648.3
    • Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      755589..756452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181261.3 → NP_011648.3  TPA: prohibitin subunit PHB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011648.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUR4, P40961
      UniProtKB/TrEMBL
      A6ZUE6, B3LI96, B5VJ77, C7GUG3, C8Z925, G2WEL4, N1P430
      Conserved Domains (1) summary
      cd03401
      Location:29 → 223
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
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