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    ppiC peptidyl-prolyl cis-trans isomerase C [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948285, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ppiC
    Official Full Name
    peptidyl-prolyl cis-trans isomerase C
    Primary source
    ECOCYC:EG12352
    Locus tag
    b3775
    See related
    ASAP:ABE-0012334
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3767; parvA
    Summary
    ppiC encodes a peptidyl-prolyl cis-trans isomerase, parvulin, which defines a new family of PPIases . [More information is available at EcoCyc: EG12352].
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    Genomic context

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    Sequence:
    NC_000913.3 (3959532..3959813, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator IlvY Neighboring gene ketol-acid reductoisomerase (NADP(+)) Neighboring gene pseudo Neighboring gene ATP-dependent DNA helicase Rep

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases. Kühlewein A, et al. Protein Sci, 2004 Sep. PMID 15322281, Free PMC Article
    2. Confirmation of the existence of a third family among peptidyl-prolyl cis/trans isomerases. Amino acid sequence and recombinant production of parvulin. Rahfeld JU, et al. FEBS Lett, 1994 Sep 26. PMID 7925971
    3. Conserved sequence motifs in bacterial and bacteriophage chaperonins. Koonin EV, et al. Trends Biochem Sci, 1995 Jan. PMID 7878732
    4. The protein-free IANUS peptide array uncovers interaction sites between Escherichia coli parvulin 10 and alkyl hydroperoxide reductase. Malesević M, et al. Biochemistry, 2010 Oct 5. PMID 20806779
    5. Peptidyl prolyl cis/trans-isomerases: comparative reactivities of cyclophilins, FK506-binding proteins, and parvulins with fluorinated oligopeptide and protein substrates. Golbik R, et al. Biochemistry, 2005 Dec 13. PMID 16331962

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: A novel peptidyl-prolyl cis/trans isomerase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase C
    NP_418223.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3959532..3959813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418223.1 peptidyl-prolyl cis-trans isomerase C [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418223.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9X1H9
      Conserved Domains (1) summary
      PRK15441
      Location:1 → 93
      PRK15441; peptidyl-prolyl cis-trans isomerase C; Provisional
    Nucleotide Protein
    Heading Accession and Version

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